Seroatlas · Human Serome Atlas

LRRC20

Leucine-rich repeat-containing protein 20

Also known as: FLJ10751, FLJ10844, LRC20_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TCA0
Gene: LRRC20
Ensembl: ENSG00000172731
Chromosome: 10
Canonical length: 184 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

No narrative summary is available for LRRC20 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

184 residues, UniProt reviewed canonical sequence.

>Q8TCA0|LRRC20
     1  MLKKMGEAVA RVARKVNETV ESGSDTLDLA ECKLVSFPIG IYKVLRNVSG QIHLITLANN
    61  ELKSLTSKFM TTFSQLRELH LEGNFLHRLP SEVSALQHLK AIDLSRNQFQ DFPEQLTALP
   121  ALETINLEEN EIVDVPVEKL AAMPALRSIN LRFNPLNAEV RVIAPPLIKF DMLMSPEGAR
   181  APLP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRRC20 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 286 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 286 nTPM
tongue: 117 nTPM
heart muscle: 36 nTPM
liver: 31 nTPM
cerebral cortex: 30 nTPM
basal ganglia: 21 nTPM

Single-cell type

myonuclei: 112 nCPM
esophageal apical cells: 101 nCPM
late spermatids: 91 nCPM
late primary spermatocytes: 62 nCPM
thyrotrophs: 47 nCPM
gonadotrophs: 44 nCPM

Immune cell

naive CD4 T-cell: 1 nTPM
myeloid DC: 0.6 nTPM
gdT-cell: 0.4 nTPM
MAIT T-cell: 0.4 nTPM
memory CD8 T-cell: 0.4 nTPM
naive CD8 T-cell: 0.4 nTPM

Brain region

cerebral cortex: 31 nTPM
pons: 24 nTPM
thalamus: 24 nTPM
white matter: 22 nTPM
amygdala: 22 nTPM
basal ganglia: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.13
gnomAD pLI: 0.04
gnomAD missense Z: 0.46
DepMap mean gene effect: 0.11
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LRRC20 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

ACTB

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRRC20 as an antibody target. Whether an autoantibody or antibody against LRRC20 could matter depends on whether native LRRC20 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRRC20 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LRRC20 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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