Seroatlas · Human Serome Atlas

LRRC57

Leucine-rich repeat-containing protein 57

Also known as: FLJ36812, LRC57_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N9N7
Gene
LRRC57
Ensembl
ENSG00000180979
Chromosome
15
Canonical length
239 aa
Protein class
Predicted intracellular proteins
Subcellular location
Mitochondria,Cytosol

OverviewNCBI Gene

Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

239 residues, UniProt reviewed canonical sequence.

>Q8N9N7|LRRC57
     1  MGNSALRAHV ETAQKTGVFQ LKDRGLTEFP ADLQKLTSNL RTIDLSNNKI ESLPPLLIGK
    61  FTLLKSLSLN NNKLTVLPDE ICNLKKLETL SLNNNHLREL PSTFGQLSAL KTLSLSGNQL
   121  GALPPQLCSL RHLDVMDLSK NQIRSIPDSV GELQVIELNL NQNQISQISV KISCCPRLKI
   181  LRLEENCLEL SMLPQSILSD SQICLLAVEG NLFEIKKLRE LEGYDKYMER FTATKKKFA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRRC57 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.25
Highest tissue expression
21 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 21 nTPM
  • retina: 14 nTPM
  • parathyroid gland: 13 nTPM
  • rectum: 10 nTPM
  • thymus: 9 nTPM
  • colon: 8.7 nTPM

Single-cell type

  • late spermatids: 12 nCPM
  • tuft cells: 12 nCPM
  • podocytes: 11 nCPM
  • papillary tip epithelial cells: 10 nCPM
  • renal collecting duct principal cells: 8.8 nCPM
  • renal collecting duct intercalated cells: 8.2 nCPM

Immune cell

  • basophil: 37 nTPM
  • eosinophil: 32 nTPM
  • non-classical monocyte: 19 nTPM
  • NK-cell: 17 nTPM
  • intermediate monocyte: 15 nTPM
  • neutrophil: 12 nTPM

Brain region

  • cerebral cortex: 22 nTPM
  • hippocampal formation: 16 nTPM
  • white matter: 14 nTPM
  • amygdala: 14 nTPM
  • cerebellum: 14 nTPM
  • basal ganglia: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.12
gnomAD pLI
0
gnomAD missense Z
0.93
DepMap mean gene effect
-0.13
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRRC57 as an antibody target. Whether an autoantibody or antibody against LRRC57 could matter depends on whether native LRRC57 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRRC57 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LRRC57 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LRRC57. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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