Seroatlas · Human Serome Atlas

LRRIQ4

Leucine-rich repeat and IQ domain-containing protein 4

Also known as: LRIQ4_HUMAN, LRRC64

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NIV6
Gene: LRRIQ4
Ensembl: ENSG00000188306
Chromosome: 3
Canonical length: 560 aa
Protein class: Predicted intracellular proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

560 residues, UniProt reviewed canonical sequence.

>A6NIV6|LRRIQ4
     1  MSKDIKSVEH SPKIHQRNDP QHVNDRTFFI DASNQSLTAI PLEIFTFTEL EEVHLENNQI
    61  EEIPQEIQRL KNIRVLYLDK NNLRSLCPAL GLLSSLESLD LSYNPIFSSS LVVVSFLHAL
   121  RELRLYQTDL KEIPVVIFKN LHHLELLGLT GNHLKCLPKE IVNQTKLREI YLKRNQFEVF
   181  PQELCVLYTL EIIDLDENKI GAIPEEIGHL TGLQKFYMAS NNLPVLPASL CQCSQLSVLD
   241  LSHNLLHSIP KSFAELRKMT EIGLSGNRLE KVPRLICRWT SLHLLYLGNT GLHRLRGSFR
   301  CLVNLRFLDL SQNHLHHCPL QICALKNLEV LGLDDNKIGQ LPSELGSLSK LKILGLTGNE
   361  FLSFPEEVLS LASLEKLYIG QDQGFKLTYV PEHIRKLQSL KELYIENNHL EYLPVSLGSM
   421  PNLEVLDCRH NLLKQLPDAI CQAQALKELR LEDNLLTHLP ENLDSLVNLK VLTLMDNPME
   481  EPPKEVCAEG NEAIWKYLKE NRNRNIMATK IQAWWRGTMV QRGFGKFGEL LKPQKKGKTS
   541  PKDKKGKKDV KGKPGKGKKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRRIQ4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 2.5 nTPM

Expression across tissuesHPA

Tissue

testis: 2.5 nTPM
small intestine: 0.4 nTPM
colon: 0.3 nTPM
retina: 0.2 nTPM
stomach: 0.2 nTPM
appendix: 0.1 nTPM

Single-cell type

early spermatids: 67 nCPM
late spermatids: 41 nCPM
adrenal medulla cells: 11 nCPM
ependymal cells: 6.4 nCPM
late primary spermatocytes: 4.8 nCPM
medullary thymic epithelial cells: 4.8 nCPM

Immune cell

memory B-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

hypothalamus: 1.4 nTPM
cerebral cortex: 1.2 nTPM
midbrain: 1.2 nTPM
thalamus: 1.2 nTPM
amygdala: 1.1 nTPM
basal ganglia: 1.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.12
gnomAD pLI: 0
gnomAD missense Z: 0.2
DepMap mean gene effect: 0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

cytoplasm

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRRIQ4 as an antibody target. Whether an autoantibody or antibody against LRRIQ4 could matter depends on whether native LRRIQ4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRRIQ4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LRRIQ4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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