RSU1
Ras suppressor protein 1
Also known as: FLJ31034, RSP-1, RSU1_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q15404
- Gene
- RSU1
- Ensembl
- ENSG00000148484
- Chromosome
- 10
- Canonical length
- 277 aa
- Protein class
- Plasma proteins, Predicted intracellular proteins
- Subcellular location
- Vesicles
OverviewNCBI Gene
This gene encodes a protein that is involved in the Ras signal transduction pathway, growth inhibition, and nerve-growth factor induced differentiation processes, as determined in mouse and human cell line studies. In mouse, the encoded protein was initially isolated based on its ability to inhibit v-Ras transformation. Multiple alternatively spliced transcript variants for this gene have been reported; one of these variants was found only in glioma tumors. [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
277 residues, UniProt reviewed canonical sequence.
>Q15404|RSU1
1 MSKSLKKLVE ESREKNQPEV DMSDRGISNM LDVNGLFTLS HITQLVLSHN KLTMVPPNIA
61 ELKNLEVLNF FNNQIEELPT QISSLQKLKH LNLGMNRLNT LPRGFGSLPA LEVLDLTYNN
121 LSENSLPGNF FYLTTLRALY LSDNDFEILP PDIGKLTKLQ ILSLRDNDLI SLPKEIGELT
181 QLKELHIQGN RLTVLPPELG NLDLTGQKQV FKAENNPWVT PIADQFQLGV SHVFEYIRSE
241 TYKYLYGRHM QANPEPPKKN NDKSKKISRK PLAAKNRLocalizationUniProt · AlphaFold · HPA
Whether an antibody against RSU1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.25
- Highest tissue expression
- 58 nTPM
Expression across tissuesHPA
Tissue
- blood vessel: 58 nTPM
- smooth muscle: 39 nTPM
- adipose tissue: 33 nTPM
- endometrium: 29 nTPM
- colon: 27 nTPM
- bone marrow: 26 nTPM
Single-cell type
- megakaryocytes: 995 nCPM
- platelets: 737 nCPM
- oocytes: 419 nCPM
- megakaryocyte progenitors: 403 nCPM
- late spermatids: 315 nCPM
- rod photoreceptor cells: 299 nCPM
Immune cell
- total PBMC: 48 nTPM
- T-reg: 36 nTPM
- myeloid DC: 35 nTPM
- basophil: 33 nTPM
- NK-cell: 31 nTPM
- memory CD4 T-cell: 28 nTPM
Brain region
- medulla oblongata: 14 nTPM
- thalamus: 14 nTPM
- choroid plexus: 13 nTPM
- hypothalamus: 13 nTPM
- white matter: 12 nTPM
- midbrain: 12 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.95
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.46
- DepMap mean gene effect
- -0.06
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of RSU1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads RSU1 as an antibody target. Whether an autoantibody or antibody against RSU1 could matter depends on whether native RSU1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
RSU1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label RSU1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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