LRRC2
Leucine-rich repeat-containing protein 2
Also known as: LRRC2_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9BYS8
- Gene
- LRRC2
- Ensembl
- ENSG00000163827
- Chromosome
- 3
- Canonical length
- 371 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Nuclear bodies,Cytosol
OverviewNCBI Gene
This gene encodes a member of the leucine-rich repeat-containing family of proteins, which function in diverse biological pathways. This family member may possibly be a nuclear protein. Similarity to the RAS suppressor protein, as well as expression down-regulation observed in tumor cells, suggests that it may function as a tumor suppressor. The gene is located in the chromosome 3 common eliminated region 1 (C3CER1), a 1.4 Mb region that is commonly deleted in diverse tumors. A related pseudogene has been identified on chromosome 2. [provided by RefSeq, Sep 2011]
Canonical amino-acid sequenceUniProt
371 residues, UniProt reviewed canonical sequence.
>Q9BYS8|LRRC2
1 MGHKVVVFDI SVIRALWETR VKKHKAWQKK EVERLEKSAL EKIKEEWNFV AECRRKGIPQ
61 AVYCKNGFID TSVRLLDKIE RNTLTRQSSL PKDRGKRSSA FVFELSGEHW TELPDSLKEQ
121 THLREWYISN TLIQIIPTYI QLFQAMRILD LPKNQISHLP AEIGCLKNLK ELNVGFNYLK
181 SIPPELGDCE NLERLDCSGN LELMELPFEL SNLKQVTFVD ISANKFSSVP ICVLRMSNLQ
241 WLDISSNNLT DLPQDIDRLE ELQSFLLYKN KLTYLPYSML NLKKLTLLVV SGDHLVELPT
301 ALCDSSTPLK FVSLMDNPID NAQCEDGNEI MESERDRQHF DKEVMKAYIE DLKERESVPS
361 YTTKVSFSLQ LLocalizationUniProt · AlphaFold · HPA
Whether an antibody against LRRC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.33
- Highest tissue expression
- 154 nTPM
Expression across tissuesHPA
Tissue
- skeletal muscle: 154 nTPM
- tongue: 88 nTPM
- heart muscle: 43 nTPM
- thyroid gland: 21 nTPM
- liver: 5.2 nTPM
- ovary: 5.1 nTPM
Single-cell type
- myonuclei: 770 nCPM
- podocytes: 552 nCPM
- cardiomyocytes: 177 nCPM
- thymic myoid cells: 177 nCPM
- medullary thymic epithelial cells: 79 nCPM
- myosatellite cells: 53 nCPM
Immune cell
- basophil: 0.5 nTPM
- T-reg: 0.5 nTPM
- neutrophil: 0.4 nTPM
- memory CD4 T-cell: 0.3 nTPM
- naive B-cell: 0.2 nTPM
- NK-cell: 0.2 nTPM
Brain region
- basal ganglia: 11 nTPM
- cerebral cortex: 9.6 nTPM
- hippocampal formation: 9 nTPM
- white matter: 6.6 nTPM
- cerebellum: 5.8 nTPM
- midbrain: 4.7 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.14
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.93
- DepMap mean gene effect
- 0.12
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads LRRC2 as an antibody target. Whether an autoantibody or antibody against LRRC2 could matter depends on whether native LRRC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
LRRC2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label LRRC2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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