LRRC10B
Leucine-rich repeat-containing protein 10B
Also known as: LR10B_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A6NIK2
- Gene
- LRRC10B
- Ensembl
- ENSG00000204950
- Chromosome
- 11
- Canonical length
- 292 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Nucleoli
OverviewNCBI Gene
No narrative summary is available for LRRC10B in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
292 residues, UniProt reviewed canonical sequence.
>A6NIK2|LRRC10B
1 MGIAESTPDE LPSDAEEQLR SGDQQLELSG RRLRRLPSAV CALSRLQKLY VSGTGLRELP
61 EEIEELRELR ILALDFNKLE RLPDGLCRLP RLTRLYLGGN RLLALPADFA QLQSLRCLWI
121 EGNFLRRFPR PLLRLVALQS LQMGDNRLRA LPAELPRMTG LRGLWLYGNR FEEFPPALLR
181 MGRLHILDLD RNRLGGFPDL HPLRALRVFS YDHNPVTGPP RVADTVFLVG EGAVERMAER
241 DEPTPRPPPR RPARAFEDEE EEDLLIGGAG SRALGAPGGS FRALEAAPGL GTLocalizationUniProt · AlphaFold · HPA
Whether an antibody against LRRC10B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.35
- Highest tissue expression
- 59 nTPM
Expression across tissuesHPA
Tissue
- basal ganglia: 59 nTPM
- pituitary gland: 32 nTPM
- fallopian tube: 27 nTPM
- hippocampal formation: 14 nTPM
- blood vessel: 13 nTPM
- cerebral cortex: 11 nTPM
Single-cell type
- respiratory ciliated cells: 225 nCPM
- fallopian tube ciliated cells: 179 nCPM
- endometrial ciliated cells: 57 nCPM
- epididymal efferent duct ciliated cells: 50 nCPM
- vascular smooth muscle cells: 38 nCPM
- pancreatic islet cells: 33 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- basal ganglia: 90 nTPM
- hippocampal formation: 29 nTPM
- cerebral cortex: 24 nTPM
- amygdala: 23 nTPM
- thalamus: 16 nTPM
- hypothalamus: 11 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.72
- gnomAD pLI
- 0.04
- gnomAD missense Z
- 1.26
- DepMap mean gene effect
- -0.13
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads LRRC10B as an antibody target. Whether an autoantibody or antibody against LRRC10B could matter depends on whether native LRRC10B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
LRRC10B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label LRRC10B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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