Seroatlas · Human Serome Atlas

LRR1

Leucine-rich repeat protein 1

Also known as: LLR1_HUMAN, LRR-1, MGC20689, PPIL5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96L50
Gene
LRR1
Ensembl
ENSG00000165501
Chromosome
14
Canonical length
414 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nuclear membrane,Vesicles

OverviewNCBI Gene

The protein encoded by this gene contains a leucine-rich repeat (LRR). It specifically interacts with TNFRSF9/4-1BB, a member of the tumor necrosis factor receptor (TNFR) superfamily. Overexpression of this gene suppresses the activation of NF-kappa B induced by TNFRSF9 or TNF receptor-associated factor 2 (TRAF2), which suggests that this protein is a negative regulator of TNFRSF9-mediated signaling cascades. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011]

Canonical amino-acid sequenceUniProt

414 residues, UniProt reviewed canonical sequence.

>Q96L50|LRR1
     1  MKLHCEVEVI SRHLPALGLR NRGKGVRAVL SLCQQTSRSQ PPVRAFLLIS TLKDKRGTRY
    61  ELRENIEQFF TKFVDEGKAT VRLKEPPVDI CLSKAISSSL KGFLSAMRLA HRGCNVDTPV
   121  STLTPVKTSE FENFKTKMVI TSKKDYPLSK NFPYSLEHLQ TSYCGLVRVD MRMLCLKSLR
   181  KLDLSHNHIK KLPATIGDLI HLQELNLNDN HLESFSVALC HSTLQKSLRS LDLSKNKIKA
   241  LPVQFCQLQE LKNLKLDDNE LIQFPCKIGQ LINLRFLSAA RNKLPFLPSE FRNLSLEYLD
   301  LFGNTFEQPK VLPVIKLQAP LTLLESSART ILHNRIPYGS HIIPFHLCQD LDTAKICVCG
   361  RFCLNSFIQG TTTMNLHSVA HTVVLVDNLG GTEAPIISYF CSLGCYVNSS DMLK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
27 nTPM

Expression across tissuesHPA

Tissue

  • testis: 27 nTPM
  • thymus: 22 nTPM
  • bone marrow: 21 nTPM
  • lymph node: 13 nTPM
  • tonsil: 12 nTPM
  • colon: 11 nTPM

Single-cell type

  • late primary spermatocytes: 346 nCPM
  • early spermatids: 104 nCPM
  • erythrocyte progenitors: 69 nCPM
  • late spermatids: 53 nCPM
  • megakaryocytes: 50 nCPM
  • monocyte progenitors: 46 nCPM

Immune cell

  • eosinophil: 26 nTPM
  • intermediate monocyte: 23 nTPM
  • basophil: 23 nTPM
  • plasmacytoid DC: 18 nTPM
  • non-classical monocyte: 17 nTPM
  • memory B-cell: 16 nTPM

Brain region

  • pons: 1.7 nTPM
  • white matter: 1.7 nTPM
  • medulla oblongata: 1.6 nTPM
  • thalamus: 1.5 nTPM
  • cerebellum: 1.4 nTPM
  • midbrain: 1.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.44
gnomAD pLI
0
gnomAD missense Z
0.3
DepMap mean gene effect
-2.31
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LRR1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRR1 as an antibody target. Whether an autoantibody or antibody against LRR1 could matter depends on whether native LRR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRR1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LRR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/LRR1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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