Seroatlas · Human Serome Atlas

LRRC30

Leucine-rich repeat-containing protein 30

Also known as: LRC30_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NM36
Gene: LRRC30
Ensembl: ENSG00000206422
Chromosome: 18
Canonical length: 301 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be involved in intracellular signal transduction. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

301 residues, UniProt reviewed canonical sequence.

>A6NM36|LRRC30
     1  MGARQSRASS KDKGPKRMLF TGRRQKFSPW DDALLSGRDP RSLLKRGMHH VSFSLVTRGM
    61  TDIPDFLWGL SEVQKLNLSH NQLRVLPPEV GKLTRIVVLN LCGNRLKSLP REVSLLQCLK
   121  VLFVNMNCLT EVPAELSLCR KLEVLSLSHN CLSQLPACFA DLSRLRKLNL SNNFFAHIPM
   181  CVFSLKELIF LHVGSNRLEN IAESIQHLAS LQIFIAEGNN IHSFPRSLCL VTSLELLNLN
   241  NNDIQTLPSE LHLLCRLVRI AWNPMDKGLH ISHNPLSKPL PELVEGGLEM LFGYLKDKKH
   301  T

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRRC30 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 15 nTPM
tongue: 4 nTPM
esophagus: 0.4 nTPM
salivary gland: 0.2 nTPM
prostate: 0.1 nTPM
adipose tissue: 0 nTPM

Single-cell type

myonuclei: 1.7 nCPM
cardiomyocytes: 0.3 nCPM
mesothelial cells: 0.3 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM
adrenal medulla cells: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.86
gnomAD pLI: 0
gnomAD missense Z: -0.43
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

intracellular signal transduction

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRRC30 as an antibody target. Whether an autoantibody or antibody against LRRC30 could matter depends on whether native LRRC30 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRRC30 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LRRC30 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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