MHC classes I/II-like antigen recognition protein
IPR011162
Definition
Major Histocompatibility Complex (MHC) glycoproteins are heterodimeric cell surface receptors that function to present antigen peptide fragments to T cells responsible for cell-mediated immune responses. MHC molecules can be subdivided into two groups on the basis of structure and function: class I molecules present intracellular antigen peptide fragments (~10 amino acids) on the surface of the host cells to cytotoxic T cells; class II molecules present exogenously derived antigenic peptides (~15 amino acids) to helper T cells. MHC class I and II molecules are assembled and loaded with their peptide ligands via different mechanisms. However, both present peptide fragments rather than entire proteins to T cells, and are required to mount an immune response. This superfamily represents MHC class I and II-like antigen-recognition domains from: MHC class II, N-terminal domains of alpha and beta chains PMID:9768757 MHC class I, alpha-1 and alpha-2 domains PMID:15454423 MHC class I related proteins, such as gammadelta T-cell ligand PMID:17291278, Ulbp3 PMID:12857997, Fc (IgG) receptor (alpha-1 and -2 domains) PMID:7969498, CD1 (alpha-1 and -2 domains) PMID:11677624, zinc-alpha-2-glycoprotein ZAG (fat depleting factor) PMID:16475792 Immunomodulatory protein m144, alpha-1 and alpha-2 domains PMID:16500675 Haemochromatosis protein Hfe, alpha-1 and alpha-2 domains PMID:12667138 NK cell ligand RAE-1 beta PMID:12594837 Endothelial protein C receptor (phospholipid-binding protein) PMID:17327234
40 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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