Seroatlas · Human Serome Atlas

RAET1L

UL16-binding protein 6

Also known as: ULBP6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5VY80
Gene: RAET1L
Ensembl: ENSG00000155918
Chromosome: 6
Canonical length: 246 aa
Protein class: Predicted membrane proteins
Subcellular location: Vesicles,Plasma membrane

OverviewNCBI Gene

RAET1L belongs to the RAET1 family of major histocompatibility complex (MHC) class I-related genes, which are located within a 180-kb cluster on chromosome 6q24.2-q25.3. The REAT1 genes encode glycoproteins that contain extracellular alpha-1 and alpha-2 domains, but they lack the membrane proximal Ig-like alpha-3 domain. Most RAET1 glycoproteins are anchored to the membrane via glycosylphosphatidylinositol (GPI) linkage (Radosavljevic et al., 2002 [PubMed 11827464]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

246 residues, UniProt reviewed canonical sequence.

>Q5VY80|RAET1L
     1  MAAAAIPALL LCLPLLFLLF GWSRARRDDP HSLCYDITVI PKFRPGPRWC AVQGQVDEKT
    61  FLHYDCGNKT VTPVSPLGKK LNVTMAWKAQ NPVLREVVDI LTEQLLDIQL ENYTPKEPLT
   121  LQARMSCEQK AEGHSSGSWQ FSIDGQTFLL FDSEKRMWTT VHPGARKMKE KWENDKDVAM
   181  SFHYISMGDC IGWLEDFLMG MDSTLEPSAG APLAMSSGTT QLRATATTLI LCCLLIILPC
   241  FILPGI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAET1L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 46 nTPM

Expression across tissuesHPA

Tissue

esophagus: 46 nTPM
vagina: 13 nTPM
cervix: 12 nTPM
salivary gland: 5.6 nTPM
tonsil: 4.9 nTPM
skin: 4 nTPM

Single-cell type

esophageal apical cells: 594 nCPM
esophageal suprabasal cells: 86 nCPM
ocular epithelial cells: 69 nCPM
epididymal basal cells: 63 nCPM
suprabasal keratinocytes: 28 nCPM
basal keratinocytes: 6.5 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.6 nTPM
hippocampal formation: 0.5 nTPM
amygdala: 0.3 nTPM
basal ganglia: 0.3 nTPM
white matter: 0.3 nTPM
cerebellum: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.86
gnomAD pLI: 0
gnomAD missense Z: -0.99
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAET1L as an antibody target. Whether an autoantibody or antibody against RAET1L could matter depends on whether native RAET1L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAET1L is annotated at the cell surface, where native RAET1L is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RAET1L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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