Seroatlas · Human Serome Atlas

CD1E

T-cell surface glycoprotein CD1e, membrane-associated

Also known as: CD1E_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P15812
Gene
CD1E
Ensembl
ENSG00000158488
Chromosome
1
Canonical length
388 aa
Protein class
CD markers, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoli,Golgi apparatus
Secretome location
Intracellular and membrane

OverviewNCBI Gene

This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes within Golgi compartments, endosomes, and lysosomes, and is cleaved into a stable soluble form. The soluble form is required for the intracellular processing of some glycolipids into a form that can be presented by other CD1 family members. Many alternatively spliced transcript variants encoding different isoforms have been described. Additional transcript variants have been found; however, their biological validity has not been determined. [provided by RefSeq, Jun 2010]

Canonical amino-acid sequenceUniProt

388 residues, UniProt reviewed canonical sequence.

>P15812|CD1E
     1  MLLLFLLFEG LCCPGENTAA PQALQSYHLA AEEQLSFRML QTSSFANHSW AHSEGSGWLG
    61  DLQTHGWDTV LGTIRFLKPW SHGNFSKQEL KNLQSLFQLY FHSFIQIVQA SAGQFQLEYP
   121  FEIQILAGCR MNAPQIFLNM AYQGSDFLSF QGISWEPSPG AGIRAQNICK VLNRYLDIKE
   181  ILQSLLGHTC PRFLAGLMEA GESELKRKVK PEAWLSCGPS PGPGRLQLVC HVSGFYPKPV
   241  WVMWMRGEQE QRGTQRGDVL PNADETWYLR ATLDVAAGEA AGLSCRVKHS SLGGHDLIIH
   301  WGGYSIFLIL ICLTVIVTLV ILVVVDSRLK KQSSNKNILS PHTPSPVFLM GANTQDTKNS
   361  RHQFCLAQVS WIKNRVLKKW KTRLNQLW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CD1E can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
895 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 895 nTPM
  • skin: 13 nTPM
  • tonsil: 9.2 nTPM
  • esophagus: 7.4 nTPM
  • lymph node: 6 nTPM
  • rectum: 5.3 nTPM

Single-cell type

  • cdc: 352 nCPM
  • macrophages: 38 nCPM
  • monocytes: 8.5 nCPM
  • platelets: 2.8 nCPM
  • epicardial cells: 2.3 nCPM
  • neutrophils: 0.9 nCPM

Immune cell

  • myeloid DC: 63 nTPM
  • classical monocyte: 4.5 nTPM
  • total PBMC: 2.6 nTPM
  • intermediate monocyte: 2.5 nTPM
  • MAIT T-cell: 0.2 nTPM
  • gdT-cell: 0.1 nTPM

Brain region

  • hypothalamus: 0.1 nTPM
  • medulla oblongata: 0.1 nTPM
  • thalamus: 0.1 nTPM
  • white matter: 0.1 nTPM
  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.73
gnomAD pLI
0
gnomAD missense Z
-0.11
DepMap mean gene effect
-0.01
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CD1E as an antibody target. Whether an autoantibody or antibody against CD1E could matter depends on whether native CD1E is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CD1E is annotated at the cell surface, where native CD1E is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CD1E as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CD1E. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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