CD1C

Protein identityUniProt · HPA

UniProt accession

P29017

Gene

CD1C

Ensembl

ENSG00000158481

Chromosome

1

Canonical length

333 aa

Protein class

CD markers, Predicted intracellular proteins, Predicted membrane proteins

Subcellular location

Endoplasmic reticulum,Golgi apparatus,Vesicles

OverviewNCBI Gene

This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene is broadly distributed throughout the endocytic system via a tyrosine-based motif in the cytoplasmic tail. Alternatively spliced transcript variants of this gene have been observed, but their full-length nature is not known. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

333 residues, UniProt reviewed canonical sequence.

>P29017|CD1C
     1  MLFLQFLLLA LLLPGGDNAD ASQEHVSFHV IQIFSFVNQS WARGQGSGWL DELQTHGWDS
    61  ESGTIIFLHN WSKGNFSNEE LSDLELLFRF YLFGLTREIQ DHASQDYSKY PFEVQVKAGC
   121  ELHSGKSPEG FFQVAFNGLD LLSFQNTTWV PSPGCGSLAQ SVCHLLNHQY EGVTETVYNL
   181  IRSTCPRFLL GLLDAGKMYV HRQVRPEAWL SSRPSLGSGQ LLLVCHASGF YPKPVWVTWM
   241  RNEQEQLGTK HGDILPNADG TWYLQVILEV ASEEPAGLSC RVRHSSLGGQ DIILYWGHHF
   301  SMNWIALVVI VPLVILIVLV LWFKKHCSYQ DIL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CD1C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.36

Highest tissue expression

121 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.23

gnomAD pLI

0

gnomAD missense Z

-0.23

DepMap mean gene effect

-0.01

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• adaptive immune response
• antigen processing and presentation, endogenous lipid antigen via MHC class Ib
• antigen processing and presentation, exogenous lipid antigen via MHC class Ib
• immune response
• positive regulation of T cell mediated cytotoxicity
• T cell activation involved in immune response

Molecular functions

• endogenous lipid antigen binding
• exogenous lipid antigen binding
• glycolipid binding
• lipopeptide binding

Cellular components

• endoplasmic reticulum
• endosome membrane
• external side of plasma membrane
• extracellular space
• Golgi apparatus
• lysosome
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Immunoglobulin C1-set
• Immunoglobulin-like domain
• MHC class I-like antigen recognition-like
• MHC classes I/II-like antigen recognition protein
• Immunoglobulin-like fold
• Immunoglobulin-like domain superfamily
• MHC class I-like antigen recognition-like superfamily
• Antigen-presenting and immune regulatory MHC class I-related
• Immunoglobulin C1-set domain
• MHC-I family domain

KeywordsUniProt

• Adaptive immunity
• Cell membrane
• Disulfide bond
• Endosome
• Glycoprotein
• Immunity
• Immunoglobulin domain
• Lipid-binding
• Lysosome
• Membrane
• Signal
• Transmembrane
• Transmembrane helix