HLA-DRB4
HLA class II histocompatibility antigen, DR beta 4 chain
Also known as: DRB4_HUMAN
Protein identityUniProt · HPA
OverviewNCBI Gene
No narrative summary is available for HLA-DRB4 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
266 residues, UniProt reviewed canonical sequence.
>P13762|HLA-DRB4
1 MVCLKLPGGS CMAALTVTLT VLSSPLALAG DTQPRFLEQA KCECHFLNGT ERVWNLIRYI
61 YNQEEYARYN SDLGEYQAVT ELGRPDAEYW NSQKDLLERR RAEVDTYCRY NYGVVESFTV
121 QRRVQPKVTV YPSKTQPLQH HNLLVCSVNG FYPGSIEVRW FRNGQEEKAG VVSTGLIQNG
181 DWTFQTLVML ETVPRSGEVY TCQVEHPSMM SPLTVQWSAR SESAQSKMLS GVGGFVLGLL
241 FLGTGLFIYF RNQKGHSGLQ PTGLLSLocalizationUniProt · AlphaFold · HPA
Whether an antibody against HLA-DRB4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.4
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about HLA-DRB4.
Disease | ImmuneIEDB
Conditions an epitope on HLA-DRB4 was assayed in.
- multiple sclerosis T cell
OntologyGO
Biological processes
- adaptive immune response
- antigen processing and presentation of exogenous peptide antigen via MHC class II
- peptide antigen assembly with MHC class II protein complex
- positive regulation of immune response
- positive regulation of T cell activation
Molecular functions
Cellular components
- clathrin-coated endocytic vesicle membrane
- endocytic vesicle membrane
- ER to Golgi transport vesicle membrane
- Golgi membrane
- late endosome membrane
- lumenal side of endoplasmic reticulum membrane
- lysosomal membrane
- MHC class II protein complex
- plasma membrane
- trans-Golgi network membrane
- transport vesicle membrane
Protein domainsUniProt · Pfam · InterPro
- MHC class II, beta chain, N-terminal
- Immunoglobulin/major histocompatibility complex, conserved site
- Immunoglobulin C1-set
- Immunoglobulin-like domain
- MHC classes I/II-like antigen recognition protein
- Immunoglobulin-like fold
- MHC class II, alpha/beta chain, N-terminal
- Immunoglobulin-like domain superfamily
- Major Histocompatibility Complex/Immunoglobulin
- Class II histocompatibility antigen, beta domain
- Immunoglobulin C1-set domain
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads HLA-DRB4 as an antibody target. Whether an autoantibody or antibody against HLA-DRB4 could matter depends on whether native HLA-DRB4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
HLA-DRB4 is annotated at the cell surface, where native HLA-DRB4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label HLA-DRB4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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