Seroatlas · Human Serome Atlas

ULBP1

UL16-binding protein 1

Also known as: RAET1I, ULBP1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BZM6
Gene: ULBP1
Ensembl: ENSG00000111981
Chromosome: 6
Canonical length: 244 aa
Protein class: Predicted membrane proteins
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a ligand of natural killer group 2, member D (NKG2D), an immune system-activating receptor on NK cells and T-cells. Binding of the encoded ligand to NKG2D leads to activation of several signal transduction pathways, including those of JAK2, STAT5, ERK and PI3K kinase/Akt. Also, in cytomegalovirus-infected cells, this ligand binds the UL16 glycoprotein and is prevented from activating the immune system. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

Canonical amino-acid sequenceUniProt

244 residues, UniProt reviewed canonical sequence.

>Q9BZM6|ULBP1
     1  MAAAASPAFL LCLPLLHLLS GWSRAGWVDT HCLCYDFIIT PKSRPEPQWC EVQGLVDERP
    61  FLHYDCVNHK AKAFASLGKK VNVTKTWEEQ TETLRDVVDF LKGQLLDIQV ENLIPIEPLT
   121  LQARMSCEHE AHGHGRGSWQ FLFNGQKFLL FDSNNRKWTA LHPGAKKMTE KWEKNRDVTM
   181  FFQKISLGDC KMWLEEFLMY WEQMLDPTKP PSLAPGTTQP KAMATTLSPW SLLIIFLCFI
   241  LAGR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ULBP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 3.6 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 3.6 nTPM
testis: 3.2 nTPM
lung: 1.5 nTPM
placenta: 0.5 nTPM
hippocampal formation: 0.4 nTPM
thyroid gland: 0.4 nTPM

Single-cell type

ocular epithelial cells: 16 nCPM
epididymal basal cells: 4.2 nCPM
cdc: 3.3 nCPM
esophageal apical cells: 2.9 nCPM
esophageal suprabasal cells: 2.6 nCPM
breast secretory cells: 1.9 nCPM

Immune cell

non-classical monocyte: 0.6 nTPM
intermediate monocyte: 0.4 nTPM
memory B-cell: 0.1 nTPM
neutrophil: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM

Brain region

cerebellum: 10 nTPM
cerebral cortex: 4.9 nTPM
hippocampal formation: 4.3 nTPM
pons: 2.1 nTPM
midbrain: 1.4 nTPM
white matter: 1.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.52
gnomAD pLI: 0
gnomAD missense Z: -1.22
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ULBP1 as an antibody target. Whether an autoantibody or antibody against ULBP1 could matter depends on whether native ULBP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ULBP1 is annotated at the cell surface, where native ULBP1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ULBP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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