PROCR

Protein identityUniProt · HPA

UniProt accession

Q9UNN8

Gene

PROCR

Ensembl

ENSG00000101000

Chromosome

20

Canonical length

238 aa

Protein class

Candidate cardiovascular disease genes, CD markers, FDA approved drug targets, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy. The encoded protein may also play a role in malarial infection and has been associated with cancer. [provided by RefSeq, Jul 2013]

Canonical amino-acid sequenceUniProt

238 residues, UniProt reviewed canonical sequence.

>Q9UNN8|PROCR
     1  MLTTLLPILL LSGWAFCSQD ASDGLQRLHM LQISYFRDPY HVWYQGNASL GGHLTHVLEG
    61  PDTNTTIIQL QPLQEPESWA RTQSGLQSYL LQFHGLVRLV HQERTLAFPL TIRCFLGCEL
   121  PPEGSRAHVF FEVAVNGSSF VSFRPERALW QADTQVTSGV VTFTLQQLNA YNRTRYELRE
   181  FLEDTCVQYV QKHISAENTK GSQTSRSYTS LVLGVLVGSF IIAGVAVGIF LCTGGRRC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PROCR can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.37

Highest tissue expression

120 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PROCR.

Disease | AutoantibodyPubMed

Conditions in which antibodies against PROCR are reported. Each links to that disease's full target list.

• Colitis, Ulcerative 3

ReferencesPubMed · IEDB

Publications for PROCR from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.05

gnomAD pLI

0.01

gnomAD missense Z

0.54

DepMap mean gene effect

-0.03

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• blood coagulation
• negative regulation of coagulation

Molecular functions

• signaling receptor activity

Cellular components

• cell surface
• centrosome
• extracellular exosome
• extracellular region
• extracellular space
• focal adhesion
• perinuclear region of cytoplasm
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• MHC class I-like antigen recognition-like
• MHC classes I/II-like antigen recognition protein
• MHC class I-like antigen recognition-like superfamily
• MHC-I family domain
• Endothelial protein C receptor

KeywordsUniProt

• Blood coagulation
• Disulfide bond
• Glycoprotein
• Hemostasis
• Membrane
• Receptor
• Signal
• Transmembrane
• Transmembrane helix