Seroatlas · Human Serome Atlas

RAET1E

Retinoic acid early transcript 1E

Also known as: bA350J20.7, LETAL, RAE1E_HUMAN, ULBP4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8TD07
Gene
RAET1E
Ensembl
ENSG00000164520
Chromosome
6
Canonical length
263 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Focal adhesion sites,Cytosol
Secretome location
Intracellular and membrane

OverviewNCBI Gene

This gene belong to the RAET1 family, which consists of major histocompatibility complex (MHC) class I-related genes located in a cluster on chromosome 6q24.2-q25.3. This and RAET1G protein differ from other RAET1 proteins in that they have type I membrane-spanning sequences at their C termini rather than glycosylphosphatidylinositol anchor sequences. This protein functions as a ligand for NKG2D receptor, which is expressed on the surface of several types of immune cells, and is involved in innate and adaptive immune responses. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

263 residues, UniProt reviewed canonical sequence.

>Q8TD07|RAET1E
     1  MRRISLTSSP VRLLLFLLLL LIALEIMVGG HSLCFNFTIK SLSRPGQPWC EAQVFLNKNL
    61  FLQYNSDNNM VKPLGLLGKK VYATSTWGEL TQTLGEVGRD LRMLLCDIKP QIKTSDPSTL
   121  QVEMFCQREA ERCTGASWQF ATNGEKSLLF DAMNMTWTVI NHEASKIKET WKKDRGLEKY
   181  FRKLSKGDCD HWLREFLGHW EAMPEPTVSP VNASDIHWSS SSLPDRWIIL GAFILLVLMG
   241  IVLICVWWQN GEWQAGLWPL RTS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAET1E can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
38 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 38 nTPM
  • vagina: 18 nTPM
  • cervix: 15 nTPM
  • skin: 11 nTPM
  • salivary gland: 7.5 nTPM
  • tonsil: 5 nTPM

Single-cell type

  • podocytes: 38 nCPM
  • suprabasal keratinocytes: 22 nCPM
  • esophageal apical cells: 13 nCPM
  • ocular epithelial cells: 8 nCPM
  • esophageal suprabasal cells: 7.7 nCPM
  • papillary tip epithelial cells: 3.8 nCPM

Immune cell

  • neutrophil: 0.3 nTPM
  • basophil: 0.2 nTPM
  • naive B-cell: 0.1 nTPM
  • NK-cell: 0.1 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM

Brain region

  • cerebellum: 4.4 nTPM
  • choroid plexus: 4.1 nTPM
  • amygdala: 3.7 nTPM
  • cerebral cortex: 3.7 nTPM
  • hypothalamus: 3.7 nTPM
  • basal ganglia: 3.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.69
gnomAD pLI
0
gnomAD missense Z
0.02
DepMap mean gene effect
0.19
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAET1E as an antibody target. Whether an autoantibody or antibody against RAET1E could matter depends on whether native RAET1E is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAET1E is annotated as secreted, so native RAET1E circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label RAET1E as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RAET1E. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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