HLA-DRB3
HLA class II histocompatibility antigen, DR beta 3 chain
Also known as: DRB3_HUMAN
Protein identityUniProt · HPA
OverviewNCBI Gene
No narrative summary is available for HLA-DRB3 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
266 residues, UniProt reviewed canonical sequence.
>P79483|HLA-DRB3
1 MVCLKLPGGS SLAALTVTLM VLSSRLAFAG DTRPRFLELR KSECHFFNGT ERVRYLDRYF
61 HNQEEFLRFD SDVGEYRAVT ELGRPVAESW NSQKDLLEQK RGRVDNYCRH NYGVGESFTV
121 QRRVHPQVTV YPAKTQPLQH HNLLVCSVSG FYPGSIEVRW FRNGQEEKAG VVSTGLIQNG
181 DWTFQTLVML ETVPRSGEVY TCQVEHPSVT SALTVEWRAR SESAQSKMLS GVGGFVLGLL
241 FLGAGLFIYF RNQKGHSGLQ PTGFLSLocalizationUniProt · AlphaFold · HPA
Whether an antibody against HLA-DRB3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.39
OntologyGO
Biological processes
- adaptive immune response
- antigen processing and presentation of exogenous peptide antigen via MHC class II
- myeloid dendritic cell antigen processing and presentation
- peptide antigen assembly with MHC class II protein complex
- positive regulation of CD4-positive, alpha-beta T cell activation
- positive regulation of immune response
- positive regulation of T cell activation
- positive regulation of T cell mediated immune response to tumor cell
- signal transduction
- T cell receptor signaling pathway
Molecular functions
Cellular components
- autolysosome membrane
- clathrin-coated endocytic vesicle membrane
- endocytic vesicle membrane
- ER to Golgi transport vesicle membrane
- Golgi membrane
- late endosome membrane
- lumenal side of endoplasmic reticulum membrane
- lysosomal membrane
- membrane
- MHC class II protein complex
- plasma membrane
- trans-Golgi network membrane
- transport vesicle membrane
Protein domainsUniProt · Pfam · InterPro
- MHC class II, beta chain, N-terminal
- Immunoglobulin/major histocompatibility complex, conserved site
- Immunoglobulin C1-set
- Immunoglobulin-like domain
- MHC classes I/II-like antigen recognition protein
- Immunoglobulin-like fold
- MHC class II, alpha/beta chain, N-terminal
- Immunoglobulin-like domain superfamily
- Major Histocompatibility Complex/Immunoglobulin
- Class II histocompatibility antigen, beta domain
- Immunoglobulin C1-set domain
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of HLA-DRB3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
- TCR
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads HLA-DRB3 as an antibody target. Whether an autoantibody or antibody against HLA-DRB3 could matter depends on whether native HLA-DRB3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
HLA-DRB3 is annotated at the cell surface, where native HLA-DRB3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label HLA-DRB3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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