HLA-DPB1

Protein identityUniProt · HPA

UniProt accession

P04440

Gene

HLA-DPB1

Ensembl

ENSG00000223865

Chromosome

6

Canonical length

258 aa

Protein class

Human disease related genes, Predicted membrane proteins

Subcellular location

Nucleoplasm,Cell Junctions

Quaternary structure

Homotrimer

OverviewNCBI Gene

HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

258 residues, UniProt reviewed canonical sequence.

>P04440|HLA-DPB1
     1  MMVLQVSAAP RTVALTALLM VLLTSVVQGR ATPENYLFQG RQECYAFNGT QRFLERYIYN
    61  REEFARFDSD VGEFRAVTEL GRPAAEYWNS QKDILEEKRA VPDRMCRHNY ELGGPMTLQR
   121  RVQPRVNVSP SKKGPLQHHN LLVCHVTDFY PGSIQVRWFL NGQEETAGVV STNLIRNGDW
   181  TFQILVMLEM TPQQGDVYTC QVEHTSLDSP VTVEWKAQSD SARSKTLTGA GGFVLGLIIC
   241  GVGIFMHRRS KKVQRGSA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HLA-DPB1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.39

Highest tissue expression

376 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.6

gnomAD pLI

0

gnomAD missense Z

1.4

DepMap mean gene effect

0.03

DepMap dependency class

none

OntologyGO

Biological processes

• adaptive immune response
• antigen processing and presentation of exogenous peptide antigen via MHC class II
• peptide antigen assembly with MHC class II protein complex
• positive regulation of immune response
• positive regulation of T cell activation
• positive regulation of T cell proliferation
• positive regulation of type II interferon production
• T cell receptor signaling pathway

Molecular functions

• MHC class II protein complex binding
• peptide antigen binding

Cellular components

• cell surface
• clathrin-coated endocytic vesicle membrane
• endocytic vesicle membrane
• ER to Golgi transport vesicle membrane
• Golgi membrane
• late endosome membrane
• lumenal side of endoplasmic reticulum membrane
• lysosomal membrane
• membrane
• MHC class II protein complex
• plasma membrane
• trans-Golgi network membrane
• transport vesicle membrane

Protein domainsUniProt · Pfam · InterPro

• MHC class II, beta chain, N-terminal
• Immunoglobulin/major histocompatibility complex, conserved site
• Immunoglobulin C1-set
• Immunoglobulin-like domain
• MHC classes I/II-like antigen recognition protein
• Immunoglobulin-like fold
• MHC class II, alpha/beta chain, N-terminal
• Immunoglobulin-like domain superfamily
• Major Histocompatibility Complex/Immunoglobulin
• Class II histocompatibility antigen, beta domain
• Immunoglobulin C1-set domain

KeywordsUniProt

• Adaptive immunity
• Cell membrane
• Disulfide bond
• Endoplasmic reticulum
• Endosome
• Glycoprotein
• Golgi apparatus
• Immunity
• Lysosome
• Membrane
• MHC II
• Signal
• Transmembrane
• Transmembrane helix