Seroatlas · Human Serome Atlas

RAET1G

UL-16 binding protein 5

Also known as: ULBP5, ULBP5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6H3X3
Gene
RAET1G
Ensembl
ENSG00000203722
Chromosome
6
Canonical length
334 aa
Protein class
Predicted membrane proteins, Predicted secreted proteins
Subcellular location
Vesicles,Plasma membrane
Secretome location
Secreted - unknown location

OverviewNCBI Gene

This gene encodes a member of the major histocompatibility complex (MHC) class I family of proteins. Although the encoded protein includes C-terminal transmembrane and cytoplasmic domains, proteolytic processing results in the removal of these domains and subsequent tethering to the plasma membrane by a glycosylphosphatidylinositol (GPI)-anchor. The encoded protein is one of several related ligands of the natural killer group 2, member D (NKG2D) receptor, which functions as an activating receptor in innate and adaptive immunity. This gene is present in a gene cluster on chromosome 6. [provided by RefSeq, Jul 2015]

Canonical amino-acid sequenceUniProt

334 residues, UniProt reviewed canonical sequence.

>Q6H3X3|RAET1G
     1  MAAAASPAFL LRLPLLLLLS SWCRTGLADP HSLCYDITVI PKFRPGPRWC AVQGQVDEKT
    61  FLHYDCGSKT VTPVSPLGKK LNVTTAWKAQ NPVLREVVDI LTEQLLDIQL ENYIPKEPLT
   121  LQARMSCEQK AEGHGSGSWQ LSFDGQIFLL FDSENRMWTT VHPGARKMKE KWENDKDMTM
   181  SFHYISMGDC TGWLEDFLMG MDSTLEPSAG APPTMSSGTA QPRATATTLI LCCLLIMCLL
   241  ICSRHSLTQS HGHHPQSLQP PPHPPLLHPT WLLRRVLWSD SYQIAKRPLS GGHVTRVTLP
   301  IIGDDSHSLP CPLALYTINN GAARYSEPLQ VSIS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RAET1G can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.44
Highest tissue expression
14 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 14 nTPM
  • adrenal gland: 7.5 nTPM
  • vagina: 5.5 nTPM
  • cervix: 3.7 nTPM
  • salivary gland: 3.2 nTPM
  • skin: 2.5 nTPM

Single-cell type

  • esophageal suprabasal cells: 78 nCPM
  • esophageal apical cells: 74 nCPM
  • ocular epithelial cells: 29 nCPM
  • suprabasal keratinocytes: 22 nCPM
  • mesothelial cells: 17 nCPM
  • esophageal basal cells: 15 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • hypothalamus: 4.9 nTPM
  • cerebral cortex: 4.7 nTPM
  • midbrain: 4.7 nTPM
  • hippocampal formation: 3.9 nTPM
  • amygdala: 3.8 nTPM
  • basal ganglia: 3.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.38
gnomAD pLI
0
gnomAD missense Z
-0.32
DepMap mean gene effect
-0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RAET1G as an antibody target. Whether an autoantibody or antibody against RAET1G could matter depends on whether native RAET1G is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RAET1G is annotated at the cell surface, where native RAET1G is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label RAET1G as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RAET1G. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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