Seroatlas · Human Serome Atlas

HLA-DRB1

HLA class II histocompatibility antigen, DRB1 beta chain

Also known as: DRB1_HUMAN, HLA-DR1B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P01911
Gene
HLA-DRB1
Ensembl
ENSG00000196126
Chromosome
6
Canonical length
266 aa
Protein class
Disease related genes, Human disease related genes, Plasma proteins, Predicted membrane proteins

OverviewNCBI Gene

HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells. The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and some alleles have increased frequencies associated with certain diseases or conditions. For example, DRB1*1302 has been related to acute and chronic hepatitis B virus persistence. There are multiple pseudogenes of this gene. [provided by RefSeq, Jul 2020]

Canonical amino-acid sequenceUniProt

266 residues, UniProt reviewed canonical sequence.

>P01911|HLA-DRB1
     1  MVCLKLPGGS CMTALTVTLM VLSSPLALSG DTRPRFLWQP KRECHFFNGT ERVRFLDRYF
    61  YNQEESVRFD SDVGEFRAVT ELGRPDAEYW NSQKDILEQA RAAVDTYCRH NYGVVESFTV
   121  QRRVQPKVTV YPSKTQPLQH HNLLVCSVSG FYPGSIEVRW FLNGQEEKAG MVSTGLIQNG
   181  DWTFQTLVML ETVPRSGEVY TCQVEHPSVT SPLTVEWRAR SESAQSKMLS GVGGFVLGLL
   241  FLGAGLFIYF RNQKGHSGLQ PTGFLS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HLA-DRB1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
574 nTPM

Expression across tissuesHPA

Tissue

  • lymph node: 574 nTPM
  • lung: 554 nTPM
  • spleen: 498 nTPM
  • small intestine: 337 nTPM
  • adipose tissue: 299 nTPM
  • breast: 232 nTPM

Single-cell type

  • cdc: 4,053 nCPM
  • macrophages: 1,241 nCPM
  • enterocytes: 959 nCPM
  • kupffer cells: 757 nCPM
  • endometrial secretory cells: 755 nCPM
  • b-cells: 581 nCPM

Immune cell

  • myeloid DC: 656 nTPM
  • total PBMC: 363 nTPM
  • intermediate monocyte: 313 nTPM
  • classical monocyte: 282 nTPM
  • naive B-cell: 210 nTPM
  • non-classical monocyte: 196 nTPM

Brain region

  • white matter: 11 nTPM
  • hypothalamus: 11 nTPM
  • choroid plexus: 9.4 nTPM
  • spinal cord: 7.3 nTPM
  • thalamus: 7.1 nTPM
  • cerebral cortex: 6.6 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about HLA-DRB1.

Disease | AllUniProt

Conditions HLA-DRB1 is implicated in, by any mechanism.

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 128 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Disease | ImmuneIEDB

Conditions an epitope on HLA-DRB1 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.16
gnomAD pLI
0
gnomAD missense Z
1.18
DepMap mean gene effect
0.11
DepMap dependency class
selective

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HLA-DRB1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

  • TCR

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HLA-DRB1 as an antibody target. Whether an autoantibody or antibody against HLA-DRB1 could matter depends on whether native HLA-DRB1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HLA-DRB1 is annotated at the cell surface, where native HLA-DRB1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label HLA-DRB1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/HLA-DRB1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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