MICB

Protein identityUniProt · HPA

UniProt accession

Q29980

Gene

MICB

Ensembl

ENSG00000204516

Chromosome

6

Canonical length

383 aa

Protein class

Disease related genes, Predicted membrane proteins

Subcellular location

Nucleoplasm,Golgi apparatus,Plasma membrane

Quaternary structure

Homodimer

OverviewNCBI Gene

This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microglobulin or bind peptides. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Canonical amino-acid sequenceUniProt

383 residues, UniProt reviewed canonical sequence.

>Q29980|MICB
     1  MGLGRVLLFL AVAFPFAPPA AAAEPHSLRY NLMVLSQDGS VQSGFLAEGH LDGQPFLRYD
    61  RQKRRAKPQG QWAENVLGAK TWDTETEDLT ENGQDLRRTL THIKDQKGGL HSLQEIRVCE
   121  IHEDSSTRGS RHFYYDGELF LSQNLETQES TVPQSSRAQT LAMNVTNFWK EDAMKTKTHY
   181  RAMQADCLQK LQRYLKSGVA IRRTVPPMVN VTCSEVSEGN ITVTCRASSF YPRNITLTWR
   241  QDGVSLSHNT QQWGDVLPDG NGTYQTWVAT RIRQGEEQRF TCYMEHSGNH GTHPVPSGKA
   301  LVLQSQRTDF PYVSAAMPCF VIIIILCVPC CKKKTSAAEG PELVSLQVLD QHPVGTGDHR
   361  DAAQLGFQPL MSATGSTGST EGT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MICB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.41

Highest tissue expression

9.4 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MICB.

Disease | AllUniProt

Conditions MICB is implicated in, by any mechanism.

• Rheumatoid arthritis (RA) MIM:180300

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.07

gnomAD pLI

0

gnomAD missense Z

0.55

DepMap mean gene effect

-0.16

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• adaptive immune response
• gamma-delta T cell activation
• immune response
• immune response-activating cell surface receptor signaling pathway
• killing of cells of another organism
• negative regulation of defense response to virus by host
• response to heat
• response to oxidative stress
• response to retinoic acid

Molecular functions

• natural killer cell lectin-like receptor binding

Cellular components

• cell surface
• external side of plasma membrane
• extracellular space
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Immunoglobulin C1-set
• Immunoglobulin-like domain
• MHC class I-like antigen recognition-like
• MHC classes I/II-like antigen recognition protein
• Immunoglobulin-like fold
• Immunoglobulin-like domain superfamily
• MHC class I-like antigen recognition-like superfamily
• Antigen-presenting and immune regulatory MHC class I-related
• Class I Histocompatibility antigen, domains alpha 1 and 2
• Immunoglobulin C1-set domain

KeywordsUniProt

• Adaptive immunity
• Cell membrane
• Cytolysis
• Disulfide bond
• Glycoprotein
• Host-virus interaction
• Immunity
• Immunoglobulin domain
• Membrane
• Signal
• Transmembrane
• Transmembrane helix