HLA-H
Putative HLA class I histocompatibility antigen, alpha chain H
Also known as: HLAH_HUMAN
Protein identityUniProt · HPA
OverviewNCBI Gene
No narrative summary is available for HLA-H in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
362 residues, UniProt reviewed canonical sequence.
>P01893|HLA-H
1 MVLMAPRTLL LLLSGALALT QTWARSHSMR YFYTTMSRPG AGEPRFISVG YVDDTQFVRF
61 DSDDASPREE PRAPWMEREG PKYWDRNTQI CKAQAQTERE NLRIALRYYN QSEGGSHTMQ
121 VMYGCDVGPD GPFLRGYEQH AYDGKDYIAL NEDLRSWTAA DMAAQITKRK WEAARRAEQR
181 RVYLEGEFVE WLRRYLENGK ETLQRADPPK THMTHHPISD HEATLRCWAL GFYPAEITLT
241 WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGEEQR YTCHVQHEGL PEPLTLRWEP
301 SSQPTVPIVG IVAGLVLLVA VVTGAVVAAV MWRKKSSDRK GGSYSQAASS NSAQGSDVSL
361 TALocalizationUniProt · AlphaFold · HPA
Whether an antibody against HLA-H can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.37
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about HLA-H.
Disease | ImmuneIEDB
Conditions an epitope on HLA-H was assayed in.
- ankylosing spondylitis T cell
OntologyGO
Biological processes
- antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent
- antigen processing and presentation of endogenous peptide antigen via MHC class Ib
- immune response
- positive regulation of T cell mediated cytotoxicity
Molecular functions
Cellular components
- azurophil granule membrane
- cell surface
- early endosome membrane
- ER to Golgi transport vesicle membrane
- external side of plasma membrane
- extracellular space
- Golgi membrane
- lumenal side of endoplasmic reticulum membrane
- MHC class I protein complex
- phagocytic vesicle membrane
- plasma membrane
- recycling endosome membrane
Protein domainsUniProt · Pfam · InterPro
- MHC class I alpha chain, alpha1 alpha2 domains
- Immunoglobulin/major histocompatibility complex, conserved site
- Immunoglobulin C1-set
- Immunoglobulin-like domain
- MHC class I, alpha chain, C-terminal
- MHC class I-like antigen recognition-like
- MHC classes I/II-like antigen recognition protein
- Immunoglobulin-like fold
- Immunoglobulin-like domain superfamily
- MHC class I-like antigen recognition-like superfamily
- Antigen-presenting and immune regulatory MHC class I-related
- Class I Histocompatibility antigen, domains alpha 1 and 2
- MHC_I C-terminus
- Immunoglobulin C1-set domain
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads HLA-H as an antibody target. Whether an autoantibody or antibody against HLA-H could matter depends on whether native HLA-H is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
HLA-H is annotated at the cell surface, where native HLA-H is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label HLA-H as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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