MR1

Protein identityUniProt · HPA

UniProt accession

Q95460

Gene

MR1

Ensembl

ENSG00000153029

Chromosome

1

Canonical length

341 aa

Protein class

FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins

Subcellular location

Plasma membrane

Secretome location

Intracellular and membrane

Quaternary structure

Homodimer

OverviewNCBI Gene

MAIT (mucosal-associated invariant T-cells) lymphocytes represent a small population of T-cells primarily found in the gut. The protein encoded by this gene is an antigen-presenting molecule that presents metabolites of microbial vitamin B to MAITs. This presentation may activate the MAITs to regulate the amounts of specific types of bacteria in the gut. Several transcript variants encoding different isoforms have been found for this gene, and a pseudogene of it has been detected about 36 kbp upstream on the same chromosome. [provided by RefSeq, Jul 2015]

Canonical amino-acid sequenceUniProt

341 residues, UniProt reviewed canonical sequence.

>Q95460|MR1
     1  MGELMAFLLP LIIVLMVKHS DSRTHSLRYF RLGVSDPIHG VPEFISVGYV DSHPITTYDS
    61  VTRQKEPRAP WMAENLAPDH WERYTQLLRG WQQMFKVELK RLQRHYNHSG SHTYQRMIGC
   121  ELLEDGSTTG FLQYAYDGQD FLIFNKDTLS WLAVDNVAHT IKQAWEANQH ELLYQKNWLE
   181  EECIAWLKRF LEYGKDTLQR TEPPLVRVNR KETFPGVTAL FCKAHGFYPP EIYMTWMKNG
   241  EEIVQEIDYG DILPSGDGTY QAWASIELDP QSSNLYSCHV EHCGVHMVLQ VPQESETIPL
   301  VMKAVSGSIV LVIVLAGVGV LVWRRRPREQ NGAIYLPTPD R

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.36

Highest tissue expression

20 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.83

gnomAD pLI

0

gnomAD missense Z

-0.34

DepMap mean gene effect

-0.03

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• antigen processing and presentation of exogenous antigen
• antigen processing and presentation of peptide antigen via MHC class I
• defense response to Gram-negative bacterium
• defense response to Gram-positive bacterium
• immune response
• innate immune response
• positive regulation of T cell mediated cytotoxicity directed against tumor cell target
• T cell differentiation in thymus

Molecular functions

• beta-2-microglobulin binding
• MHC class I receptor activity
• T cell receptor binding

Cellular components

• early endosome membrane
• endoplasmic reticulum
• endoplasmic reticulum membrane
• external side of plasma membrane
• extracellular space
• Golgi membrane
• late endosome membrane
• MHC class I protein complex
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• MHC class I alpha chain, alpha1 alpha2 domains
• Immunoglobulin/major histocompatibility complex, conserved site
• Immunoglobulin C1-set
• Immunoglobulin-like domain
• MHC class I-like antigen recognition-like
• MHC classes I/II-like antigen recognition protein
• Immunoglobulin-like fold
• Immunoglobulin-like domain superfamily
• MHC class I-like antigen recognition-like superfamily
• Antigen-presenting and immune regulatory MHC class I-related
• Class I Histocompatibility antigen, domains alpha 1 and 2
• Immunoglobulin C1-set domain

KeywordsUniProt

• Cell membrane
• Disulfide bond
• Endoplasmic reticulum
• Endosome
• Glycoprotein
• Golgi apparatus
• Immunity
• Immunoglobulin domain
• Innate immunity
• Membrane
• MHC I
• Secreted
• Signal
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of MR1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• TAPBP
• TAPBPL