HLA-DQA2

Protein identityUniProt · HPA

UniProt accession

P01906

Gene

HLA-DQA2

Ensembl

ENSG00000237541

Chromosome

6

Canonical length

255 aa

Protein class

Human disease related genes, Predicted membrane proteins

Quaternary structure

Homotrimer

OverviewNCBI Gene

This gene belongs to the HLA class II alpha chain family. The encoded protein forms a heterodimer with a class II beta chain. It is located in intracellular vesicles and plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (B lymphocytes, dendritic cells, macrophages) and are used to present antigenic peptides on the cell surface to be recognized by CD4 T-cells. [provided by RefSeq, Jun 2010]

Canonical amino-acid sequenceUniProt

255 residues, UniProt reviewed canonical sequence.

>P01906|HLA-DQA2
     1  MILNKALLLG ALALTAVMSP CGGEDIVADH VASYGVNFYQ SHGPSGQYTH EFDGDEEFYV
    61  DLETKETVWQ LPMFSKFISF DPQSALRNMA VGKHTLEFMM RQSNSTAATN EVPEVTVFSK
   121  FPVTLGQPNT LICLVDNIFP PVVNITWLSN GHSVTEGVSE TSFLSKSDHS FFKISYLTFL
   181  PSADEIYDCK VEHWGLDEPL LKHWEPEIPA PMSELTETLV CALGLSVGLM GIVVGTVFII
   241  QGLRSVGASR HQGLL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HLA-DQA2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.39

Highest tissue expression

26 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.6

gnomAD pLI

0

gnomAD missense Z

-0.27

DepMap mean gene effect

0

DepMap dependency class

none

OntologyGO

Biological processes

• adaptive immune response
• antigen processing and presentation of exogenous peptide antigen via MHC class II
• immune response
• peptide antigen assembly with MHC class II protein complex
• positive regulation of immune response
• positive regulation of T cell activation

Molecular functions

• MHC class II protein complex binding
• MHC class II receptor activity
• peptide antigen binding

Cellular components

• clathrin-coated endocytic vesicle membrane
• endocytic vesicle membrane
• ER to Golgi transport vesicle membrane
• Golgi membrane
• late endosome membrane
• lumenal side of endoplasmic reticulum membrane
• lysosomal membrane
• MHC class II protein complex
• plasma membrane
• trans-Golgi network membrane
• transport vesicle membrane

Protein domainsUniProt · Pfam · InterPro

• MHC class II, alpha chain, N-terminal
• Immunoglobulin/major histocompatibility complex, conserved site
• Immunoglobulin C1-set
• Immunoglobulin-like domain
• MHC classes I/II-like antigen recognition protein
• Immunoglobulin-like fold
• MHC class II, alpha/beta chain, N-terminal
• Immunoglobulin-like domain superfamily
• Major Histocompatibility Complex/Immunoglobulin
• Class II histocompatibility antigen, alpha domain
• Immunoglobulin C1-set domain

KeywordsUniProt

• Adaptive immunity
• Cell membrane
• Disulfide bond
• Endoplasmic reticulum
• Endosome
• Glycoprotein
• Golgi apparatus
• Immunity
• Lysosome
• Membrane
• MHC II
• Signal
• Transmembrane
• Transmembrane helix