Seroatlas · Human Serome Atlas

ULBP3

UL16-binding protein 3

Also known as: RAET1N, ULBP3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BZM4
Gene: ULBP3
Ensembl: ENSG00000131019
Chromosome: 6
Canonical length: 244 aa
Protein class: Predicted intracellular proteins
Subcellular location: Golgi apparatus,Vesicles
Secretome location: Intracellular and membrane

OverviewNCBI Gene

The protein encoded by this gene is one of several related ligands of the KLRK1/NKG2D receptor, which is found in primary NK cells. Binding of these ligands to the receptor activates several signal transduction pathways, including the JAK2, STAT5, and ERK pathways. The encoded protein is expressed solubly and on the surface of many tumor cells, making it potentially an important target for therapeutics. [provided by RefSeq, Nov 2015]

Canonical amino-acid sequenceUniProt

244 residues, UniProt reviewed canonical sequence.

>Q9BZM4|ULBP3
     1  MAAAASPAIL PRLAILPYLL FDWSGTGRAD AHSLWYNFTI IHLPRHGQQW CEVQSQVDQK
    61  NFLSYDCGSD KVLSMGHLEE QLYATDAWGK QLEMLREVGQ RLRLELADTE LEDFTPSGPL
   121  TLQVRMSCEC EADGYIRGSW QFSFDGRKFL LFDSNNRKWT VVHAGARRMK EKWEKDSGLT
   181  TFFKMVSMRD CKSWLRDFLM HRKKRLEPTA PPTMAPGLAQ PKAIATTLSP WSFLIILCFI
   241  LPGI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ULBP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 6.1 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 6.1 nTPM
testis: 5.9 nTPM
thyroid gland: 4.6 nTPM
fallopian tube: 1.9 nTPM
stomach: 1.8 nTPM
esophagus: 1.7 nTPM

Single-cell type

ocular epithelial cells: 14 nCPM
tuft cells: 12 nCPM
endometrial secretory cells: 9.7 nCPM
alveolar cells type 1: 6.6 nCPM
hepatic stellate cells: 6.5 nCPM
epididymal basal cells: 6.2 nCPM

Immune cell

MAIT T-cell: 2.9 nTPM
memory CD8 T-cell: 2.4 nTPM
T-reg: 2.3 nTPM
gdT-cell: 2.2 nTPM
memory CD4 T-cell: 1.5 nTPM
naive CD8 T-cell: 1.2 nTPM

Brain region

cerebral cortex: 11 nTPM
hippocampal formation: 10 nTPM
white matter: 10 nTPM
basal ganglia: 9.6 nTPM
hypothalamus: 9.6 nTPM
cerebellum: 9.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.85
gnomAD pLI: 0
gnomAD missense Z: -0.44
DepMap mean gene effect: 0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

natural killer cell lectin-like receptor binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ULBP3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

UL142

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ULBP3 as an antibody target. Whether an autoantibody or antibody against ULBP3 could matter depends on whether native ULBP3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ULBP3 is annotated at the cell surface, where native ULBP3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ULBP3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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