Seroatlas · Human Serome Atlas

MICA

MHC class I polypeptide-related sequence A

Also known as: MICA_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q29983
Gene: MICA
Canonical length: 383 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

No narrative summary is available for MICA in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

383 residues, UniProt reviewed canonical sequence.

>Q29983|MICA
     1  MGLGPVFLLL AGIFPFAPPG AAAEPHSLRY NLTVLSWDGS VQSGFLTEVH LDGQPFLRCD
    61  RQKCRAKPQG QWAEDVLGNK TWDRETRDLT GNGKDLRMTL AHIKDQKEGL HSLQEIRVCE
   121  IHEDNSTRSS QHFYYDGELF LSQNLETKEW TMPQSSRAQT LAMNVRNFLK EDAMKTKTHY
   181  HAMHADCLQE LRRYLKSGVV LRRTVPPMVN VTRSEASEGN ITVTCRASGF YPWNITLSWR
   241  QDGVSLSHDT QQWGDVLPDG NGTYQTWVAT RICQGEEQRF TCYMEHSGNH STHPVPSGKV
   301  LVLQSHWQTF HVSAVAAAAI FVIIIFYVRC CKKKTSAAEG PELVSLQVLD QHPVGTSDHR
   361  DATQLGFQPL MSDLGSTGST EGA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MICA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 51 nTPM

Expression across tissuesHPA

Tissue

ovary: 51 nTPM
blood vessel: 49 nTPM
lung: 43 nTPM
cervix: 43 nTPM
vagina: 40 nTPM
colon: 37 nTPM

Single-cell type

podocytes: 59 nCPM
loop of henle epithelial cells: 30 nCPM
renal collecting duct principal cells: 25 nCPM
distal convoluted tubule cells: 24 nCPM
paneth cells: 23 nCPM
proximal tubule cells: 23 nCPM

Immune cell

eosinophil: 1.7 nTPM
neutrophil: 1.3 nTPM
intermediate monocyte: 1 nTPM
naive CD4 T-cell: 1 nTPM
T-reg: 1 nTPM
MAIT T-cell: 0.9 nTPM

Brain region

white matter: 13 nTPM
cerebellum: 11 nTPM
cerebral cortex: 10 nTPM
medulla oblongata: 9.8 nTPM
choroid plexus: 9.7 nTPM
midbrain: 9.3 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MICA.

Disease | AllUniProt

Conditions MICA is implicated in, by any mechanism.

Psoriasis 1 (PSORS1) MIM:177900
Psoriatic arthritis (PSORAS) MIM:607507

ReferencesPubMed · IEDB

Publications for MICA from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Reference: AutoantibodyPubMed

13 publications

Development of antibodies to human leukocyte antigen precedes development of antibodies to major histocompatibility class I-related chain A and are significantly associated with development of chronic rejection after human lung transplantation.
2010 · Hum Immunol · RCR 1.5 · 49 citations
Early renal graft function deterioration in recipients with preformed anti-MICA antibodies: partial contribution of complement-dependent cytotoxicity.
2016 · Nephrol Dial Transplant · RCR 0.9 · 19 citations
The clinical relevance of pre-formed anti-HLA and anti-MICA antibodies after cord blood transplantation in children.
2013 · PLoS One · RCR 0.8 · 22 citations
Identification of epitopes and immunodominant regions on the MICA protein defined by alloantibodies from kidney transplant patients.
2009 · Transplantation · RCR 0.5 · 20 citations
The emerging issue of MICA antibodies: antibodies to MICA and other antigens of endothelial cells.
2009 · Contrib Nephrol · RCR 0.5 · 15 citations

Show 8 more

Longitudinal assessment of HLA and MIC-A antibodies in uneventful pregnancies and pregnancies complicated by preeclampsia or gestational diabetes.
2017 · Sci Rep · RCR 0.4 · 11 citations
Autoantibody Profiles in Collagen Disease Patients with Interstitial Lung Disease (ILD): Antibodies to Major Histocompatibility Complex Class I-Related Chain A (MICA) as Markers of ILD.
2015 · Biomark Insights · RCR 0.3 · 8 citations
Pre-transplant presence of antibodies to MICA and HLA class I or II are associated with an earlier onset of bronchiolitis obliterans syndrome in lung transplant recipients.
2012 · Clin Transpl · RCR 0.3 · 10 citations
Donor non-specific MICA antibodies in renal transplant recipients.
2014 · Immunobiology · RCR 0.2 · 6 citations
Antibody-Mediated Rejection in Kidney Transplantation Without Evidence of Anti-HLA Antibodies?
2016 · Transplant Proc · RCR 0.2 · 3 citations
The effect of anti-human leukocyte antigen, anti-major histocompatibility complex class 1 chain-related antigen a, and anti-glutathione transferase-T1 antibodies on the long-term survival of renal allograft.
2013 · Transplant Proc · RCR 0.1 · 3 citations
Association of de novo human leukocyte antigen and major histocompatibility complex class I chain-related gene-A antibodies and proteinuria with graft survival 5 years after renal transplantation.
2013 · Transplant Proc · RCR 0.1 · 3 citations
Autoantibodies against MHC class I polypeptide-related sequence A are associated with increased risk of concomitant autoimmune diseases in celiac patients.
2014 · BMC Med · RCR 0.1 · 3 citations

Reference: B cellIEDB

1 publication

Identification of epitopes and immunodominant regions on the MICA protein defined by alloantibodies from kidney transplant patients.
2009 · Transplantation · RCR 0.5 · 20 citations

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. IEDB — curated epitope assays from the Immune Epitope Database (Vita et al., Nucleic Acids Research 2019). Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.85
gnomAD pLI: 0
gnomAD missense Z: 0.8
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MICA as an antibody target. Whether an autoantibody or antibody against MICA could matter depends on whether native MICA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MICA is annotated at the cell surface, where native MICA is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label MICA as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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