AZGP1

Protein identityUniProt · HPA

UniProt accession

P25311

Gene

AZGP1

Ensembl

ENSG00000160862

Chromosome

7

Canonical length

298 aa

Protein class

Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins

Subcellular location

Nucleoplasm,Vesicles

Secretome location

Secreted to blood

OverviewNCBI Gene

Predicted to enable RNA nuclease activity and protein transmembrane transporter activity. Involved in cell adhesion and detection of chemical stimulus involved in sensory perception of bitter taste. Located in extracellular space. Implicated in prostate carcinoma. Biomarker of several diseases, including gastrointestinal system cancer (multiple); kidney failure (multiple); liver cirrhosis; lung adenocarcinoma; and obesity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

298 residues, UniProt reviewed canonical sequence.

>P25311|AZGP1
     1  MVRMVPVLLS LLLLLGPAVP QENQDGRYSL TYIYTGLSKH VEDVPAFQAL GSLNDLQFFR
    61  YNSKDRKSQP MGLWRQVEGM EDWKQDSQLQ KAREDIFMET LKDIVEYYND SNGSHVLQGR
   121  FGCEIENNRS SGAFWKYYYD GKDYIEFNKE IPAWVPFDPA AQITKQKWEA EPVYVQRAKA
   181  YLEEECPATL RKYLKYSKNI LDRQDPPSVV VTSHQAPGEK KKLKCLAYDF YPGKIDVHWT
   241  RAGEVQEPEL RGDVLHNGNG TYQSWVVVAV PPQDTAPYSC HVQHSSLAQP LVVPWEAS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AZGP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.32

Highest tissue expression

3,617 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about AZGP1.

Disease | ImmuneIEDB

Conditions an epitope on AZGP1 was assayed in.

• rheumatoid arthritis B cell

ReferencesPubMed · IEDB

Publications for AZGP1 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. IEDB — curated epitope assays from the Immune Epitope Database (Vita et al., Nucleic Acids Research 2019). Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.48

gnomAD pLI

0

gnomAD missense Z

-0.57

DepMap mean gene effect

-0.11

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent
• antigen processing and presentation of endogenous peptide antigen via MHC class Ib
• cell adhesion
• detection of chemical stimulus involved in sensory perception of bitter taste
• immune response
• negative regulation of cell population proliferation
• positive regulation of T cell mediated cytotoxicity

Molecular functions

• protein transmembrane transporter activity
• RNA nuclease activity

Cellular components

• external side of plasma membrane
• extracellular exosome
• extracellular region
• extracellular space
• nucleus

Protein domainsUniProt · Pfam · InterPro

• MHC class I alpha chain, alpha1 alpha2 domains
• Immunoglobulin/major histocompatibility complex, conserved site
• Immunoglobulin C1-set
• Immunoglobulin-like domain
• MHC class I-like antigen recognition-like
• MHC classes I/II-like antigen recognition protein
• Immunoglobulin-like fold
• Immunoglobulin-like domain superfamily
• MHC class I-like antigen recognition-like superfamily
• Antigen-presenting and immune regulatory MHC class I-related
• Class I Histocompatibility antigen, domains alpha 1 and 2
• Immunoglobulin C1-set domain

KeywordsUniProt

• Disulfide bond
• Glycoprotein
• Pyrrolidone carboxylic acid
• Secreted
• Signal

InteractionsUniProt · HPA

Protein binding partners of AZGP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• PIP
• UBQLN2