HLA-DQB1
HLA class II histocompatibility antigen, DQ beta 1 chain
Also known as: DQB1_HUMAN
Protein identityUniProt · HPA
- UniProt accession
- P01920
- Gene
- HLA-DQB1
- Canonical length
- 261 aa
- Protein class
- Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins
- Quaternary structure
- Homotrimer
OverviewNCBI Gene
No narrative summary is available for HLA-DQB1 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
261 residues, UniProt reviewed canonical sequence.
>P01920|HLA-DQB1
1 MSWKKALRIP GGLRAATVTL MLAMLSTPVA EGRDSPEDFV YQFKAMCYFT NGTERVRYVT
61 RYIYNREEYA RFDSDVEVYR AVTPLGPPDA EYWNSQKEVL ERTRAELDTV CRHNYQLELR
121 TTLQRRVEPT VTISPSRTEA LNHHNLLVCS VTDFYPAQIK VRWFRNDQEE TTGVVSTPLI
181 RNGDWTFQIL VMLEMTPQHG DVYTCHVEHP SLQNPITVEW RAQSESAQSK MLSGIGGFVL
241 GLIFLGLGLI IHHRSQKGLL HLocalizationUniProt · AlphaFold · HPA
Whether an antibody against HLA-DQB1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.4
- Highest tissue expression
- 291 nTPM
Expression across tissuesHPA
Tissue
- lymph node: 291 nTPM
- lung: 173 nTPM
- spleen: 138 nTPM
- stomach: 124 nTPM
- epididymis: 122 nTPM
- tonsil: 118 nTPM
Single-cell type
- cdc: 1,348 nCPM
- enterocytes: 416 nCPM
- b-cells: 350 nCPM
- macrophages: 347 nCPM
- kupffer cells: 298 nCPM
- pdcs: 234 nCPM
Immune cell
- myeloid DC: 392 nTPM
- total PBMC: 219 nTPM
- naive B-cell: 171 nTPM
- memory B-cell: 162 nTPM
- classical monocyte: 150 nTPM
- intermediate monocyte: 141 nTPM
Brain region
- white matter: 7.7 nTPM
- midbrain: 6 nTPM
- medulla oblongata: 5.9 nTPM
- spinal cord: 5.9 nTPM
- hypothalamus: 4.5 nTPM
- thalamus: 3.7 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about HLA-DQB1.
Disease | GeneticClinVar
1 pathogenic / likely-pathogenic of 59 ClinVar records.
Conditions with pathogenic or likely-pathogenic variants.
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.94
- gnomAD pLI
- 0.01
- gnomAD missense Z
- 1.31
- DepMap mean gene effect
- 0.24
- DepMap dependency class
- none
OntologyGO
Biological processes
- adaptive immune response
- antigen processing and presentation of exogenous peptide antigen via MHC class II
- humoral immune response
- immune response
- peptide antigen assembly with MHC class II protein complex
- positive regulation of immune response
- positive regulation of T cell activation
- T cell receptor signaling pathway
Molecular functions
Cellular components
- clathrin-coated endocytic vesicle membrane
- endocytic vesicle membrane
- ER to Golgi transport vesicle membrane
- Golgi membrane
- late endosome membrane
- lumenal side of endoplasmic reticulum membrane
- lysosomal membrane
- membrane
- MHC class II protein complex
- plasma membrane
- trans-Golgi network membrane
- transport vesicle membrane
Protein domainsUniProt · Pfam · InterPro
- MHC class II, beta chain, N-terminal
- Immunoglobulin/major histocompatibility complex, conserved site
- Immunoglobulin C1-set
- Immunoglobulin-like domain
- MHC classes I/II-like antigen recognition protein
- Immunoglobulin-like fold
- MHC class II, alpha/beta chain, N-terminal
- Immunoglobulin-like domain superfamily
- Major Histocompatibility Complex/Immunoglobulin
- Class II histocompatibility antigen, beta domain
- Immunoglobulin C1-set domain
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads HLA-DQB1 as an antibody target. Whether an autoantibody or antibody against HLA-DQB1 could matter depends on whether native HLA-DQB1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
HLA-DQB1 is annotated at the cell surface, where native HLA-DQB1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label HLA-DQB1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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