Seroatlas · Human Serome Atlas

ULBP2

UL16-binding protein 2

Also known as: RAET1H, ULBP2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BZM5
Gene: ULBP2
Ensembl: ENSG00000131015
Chromosome: 6
Canonical length: 246 aa
Protein class: Predicted membrane proteins, Predicted secreted proteins
Subcellular location: Vesicles,Plasma membrane
Secretome location: Secreted in other tissues

OverviewNCBI Gene

This gene encodes a major histocompatibility complex (MHC) class I-related molecule that binds to the NKG2D receptor on natural killer (NK) cells to trigger release of multiple cytokines and chemokines that in turn contribute to the recruitment and activation of NK cells. The encoded protein undergoes further processing to generate the mature protein that is either anchored to membrane via a glycosylphosphatidylinositol moiety, or secreted. Many malignant cells secrete the encoded protein to evade immunosurveillance by NK cells. This gene is located in a cluster of multiple MHC class I-related genes on chromosome 6. [provided by RefSeq, Jul 2015]

Canonical amino-acid sequenceUniProt

246 residues, UniProt reviewed canonical sequence.

>Q9BZM5|ULBP2
     1  MAAAAATKIL LCLPLLLLLS GWSRAGRADP HSLCYDITVI PKFRPGPRWC AVQGQVDEKT
    61  FLHYDCGNKT VTPVSPLGKK LNVTTAWKAQ NPVLREVVDI LTEQLRDIQL ENYTPKEPLT
   121  LQARMSCEQK AEGHSSGSWQ FSFDGQIFLL FDSEKRMWTT VHPGARKMKE KWENDKVVAM
   181  SFHYFSMGDC IGWLEDFLMG MDSTLEPSAG APLAMSSGTT QLRATATTLI LCCLLIILPC
   241  FILPGI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ULBP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 5.9 nTPM

Expression across tissuesHPA

Tissue

esophagus: 5.9 nTPM
lung: 3.3 nTPM
cerebellum: 2.6 nTPM
heart muscle: 1.9 nTPM
cerebral cortex: 1.8 nTPM
bone marrow: 1.7 nTPM

Single-cell type

ocular epithelial cells: 44 nCPM
esophageal apical cells: 16 nCPM
esophageal suprabasal cells: 15 nCPM
late spermatids: 13 nCPM
pancreatic acinar cells: 13 nCPM
epididymal basal cells: 10 nCPM

Immune cell

gdT-cell: 2.7 nTPM
naive CD8 T-cell: 1.8 nTPM
T-reg: 1.7 nTPM
memory CD8 T-cell: 1.5 nTPM
memory CD4 T-cell: 0.8 nTPM
total PBMC: 0.5 nTPM

Brain region

hippocampal formation: 5 nTPM
cerebral cortex: 4.2 nTPM
pons: 2.6 nTPM
white matter: 2.3 nTPM
cerebellum: 2.1 nTPM
basal ganglia: 1.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.85
gnomAD pLI: 0
gnomAD missense Z: -1.36
DepMap mean gene effect: -0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ULBP2 as an antibody target. Whether an autoantibody or antibody against ULBP2 could matter depends on whether native ULBP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ULBP2 is annotated at the cell surface, where native ULBP2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ULBP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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