K Homology domain
IPR004087
Definition
The K homology (KH) domain was first identified in the human heterogeneous nuclear ribonucleoprotein (hnRNP) K. An evolutionarily conserved sequence of around 70 amino acids, the KH domain is present in a wide variety of nucleic acid-binding proteins. The KH domain binds RNA, and can function in RNA recognition PMID:17437720. It is found in multiple copies in several proteins, where they can function cooperatively or independently. For example, in the AU-rich element RNA-binding protein KSRP, which has 4 KH domains, KH domains 3 and 4 behave as independent binding modules to interact with different regions of the AU-rich RNA targets PMID:17437720. The solution structure of the first KH domain of FMR1 PMID:9302998 and of the C-terminal KH domain of hnRNP K PMID:10369774 determined by nuclear magnetic resonance (NMR) revealed a β-α-α-β-β-α structure. Proteins containing KH domains include: Bacterial and organelle PNPases PMID:17337072. Archaeal and eukaryotic exosome subunits PMID:17159918. Eukaryotic and prokaryotic small ribosomal subunit proteins uS3 PMID:1160884. Vertebrate Fragile X messenger ribonucleoprotein 1 (FMR1) PMID:15805463. Vigilin, which has 14 KH domains PMID:14618268. AU-rich element RNA-binding protein KSRP. hnRNP K, which contains 3 KH domains. Human onconeural ventral antigen-1 (NOVA-1) PMID:10368286. According to structural analyses [[cite:PMID:9302998], [cite:PMID:10369774], [cite:PMID:11160884]], the KH domain can be separated in two groups - type 1 and type 2.
36 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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