Seroatlas · Human Serome Atlas

MEX3A

RNA-binding protein MEX3A

Also known as: MEX3A_HUMAN, RKHD4, RNF162

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A1L020
Gene: MEX3A
Ensembl: ENSG00000254726
Chromosome: 1
Canonical length: 520 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Enables RNA binding activity. Located in P-body and cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

520 residues, UniProt reviewed canonical sequence.

>A1L020|MEX3A
     1  MPSLVVSGIM ERNGGFGELG CFGGSAKDRG LLEDERALQL ALDQLCLLGL GEPPAPTAGE
    61  DGGGGGGGAP AQPAAPPQPA PPPPPAAPPA APTAAPAAQT PQPPTAPKGA SDAKLCALYK
   121  EAELRLKGSS NTTECVPVPT SEHVAEIVGR QGCKIKALRA KTNTYIKTPV RGEEPVFMVT
   181  GRREDVATAR REIISAAEHF SMIRASRNKS GAAFGVAPAL PGQVTIRVRV PYRVVGLVVG
   241  PKGATIKRIQ QQTNTYIITP SRDRDPVFEI TGAPGNVERA REEIETHIAV RTGKILEYNN
   301  ENDFLAGSPD AAIDSRYSDA WRVHQPGCKP LSTFRQNSLG CIGECGVDSG FEAPRLGEQG
   361  GDFGYGGYLF PGYGVGKQDV YYGVAETSPP LWAGQENATP TSVLFSSASS SSSSSAKARA
   421  GPPGAHRSPA TSAGPELAGL PRRPPGEPLQ GFSKLGGGGL RSPGGGRDCM VCFESEVTAA
   481  LVPCGHNLFC MECAVRICER TDPECPVCHI TATQAIRIFS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MEX3A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 5.6 nTPM

Expression across tissuesHPA

Tissue

ovary: 5.6 nTPM
endometrium: 3 nTPM
cervix: 2.2 nTPM
cerebral cortex: 2 nTPM
breast: 1.1 nTPM
salivary gland: 1 nTPM

Single-cell type

respiratory ionocytes: 31 nCPM
breast secretory cells: 30 nCPM
granulosa cells: 23 nCPM
breast myoepithelial cells: 14 nCPM
gastric progenitor cells: 12 nCPM
breast hormone-responsive cells: 11 nCPM

Immune cell

naive B-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebellum: 2.1 nTPM
medulla oblongata: 2.1 nTPM
spinal cord: 2 nTPM
thalamus: 1.9 nTPM
white matter: 1.7 nTPM
amygdala: 1.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.25
gnomAD pLI: 0.98
gnomAD missense Z: 2.79
DepMap mean gene effect: -0.19
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MEX3A as an antibody target. Whether an autoantibody or antibody against MEX3A could matter depends on whether native MEX3A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MEX3A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MEX3A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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