MEX3B

Protein identityUniProt · HPA

UniProt accession

Q6ZN04

Gene

MEX3B

Ensembl

ENSG00000183496

Chromosome

15

Canonical length

569 aa

Protein class

Predicted intracellular proteins

Subcellular location

Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes an RNA-binding phosphoprotein that is part of the MEX3 (muscle excess 3) family of translational regulators. The encoded protein contains N-terminal nuclear export and nuclear localization signals and is exported from the cytoplasm to the nucleus. The protein binds to RNA via two KH domains and also colocalizes with MEX3A, Dcp1A decapping factor and Argonaute proteins within P (processing) bodies. [provided by RefSeq, Oct 2012]

Canonical amino-acid sequenceUniProt

569 residues, UniProt reviewed canonical sequence.

>Q6ZN04|MEX3B
     1  MPSSLFADLE RNGSGGGGGG SSGGGETLDD QRALQLALDQ LSLLGLDSDE GASLYDSEPR
    61  KKSVNMTECV PVPSSEHVAE IVGRQGCKIK ALRAKTNTYI KTPVRGEEPV FVVTGRKEDV
   121  AMARREIISA AEHFSMIRAS RNKNTALNGA VPGPPNLPGQ TTIQVRVPYR VVGLVVGPKG
   181  ATIKRIQQQT HTYIVTPSRD KEPVFEVTGM PENVDRAREE IEAHIALRTG GIIELTDEND
   241  FHANGTDVGF DLHHGSGGSG PGSLWSKPTP SITPTPGRKP FSSYRNDSSS SLGSASTDSY
   301  FGGGTSSSAA ATQRLADYSP PSPALSFAHN GNNNNNGNGY TYTAGGEASV PSPDGCPELQ
   361  PTFDPAPAPP PGAPLIWAQF ERSPGGGPAA PVSSSCSSSA SSSASSSSVV FPGGGASAPS
   421  NANLGLLVHR RLHPGTSCPR LSPPLHMAPG AGEHHLARRV RSDPGGGGLA YAAYANGLGA
   481  QLPGLQPSDT SGSSSSSSSS SSSSSSSSGL RRKGSRDCSV CFESEVIAAL VPCGHNLFCM
   541  ECANRICEKS EPECPVCHTA VTQAIRIFS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MEX3B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.58

Highest tissue expression

45 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.57

gnomAD pLI

0.56

gnomAD missense Z

1.06

DepMap mean gene effect

-0.11

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• protein autophosphorylation
• protein phosphorylation

Molecular functions

• calcium ion binding
• RNA binding
• zinc ion binding

Cellular components

• cytosol
• nucleoplasm
• P-body

Protein domainsUniProt · Pfam · InterPro

• Zinc finger, RING-type
• K Homology domain
• K Homology domain, type 1
• Zinc finger, RING/FYVE/PHD-type
• K Homology domain, type 1 superfamily
• RNA-binding protein MEX-3, second type I KH domain
• RNA-binding protein MEX3
• RNA-binding protein MEX-3, first type I KH domain
• KH domain
• Zinc finger, C3HC4 type (RING finger)

KeywordsUniProt

• Cytoplasm
• Metal-binding
• Nucleus
• Phosphoprotein
• Repeat
• RNA-binding
• Zinc
• Zinc-finger

InteractionsUniProt · HPA

Protein binding partners of MEX3B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• UBE2D3