Seroatlas · Human Serome Atlas

PCBP4

Poly(rC)-binding protein 4

Also known as: LIP4, MCG10, PCBP4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P57723
Gene: PCBP4
Ensembl: ENSG00000090097
Chromosome: 3
Canonical length: 403 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

This gene encodes a member of the KH-domain protein subfamily. Proteins of this subfamily, also referred to as alpha-CPs, bind to RNA with a specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. This gene is induced by the p53 tumor suppressor, and the encoded protein can suppress cell proliferation by inducing apoptosis and cell cycle arrest in G(2)-M. This gene's protein is found in the cytoplasm, yet it lacks the nuclear localization signals found in other subfamily members. Multiple alternatively spliced transcript variants have been described, but the full-length nature for only some has been determined. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

403 residues, UniProt reviewed canonical sequence.

>P57723|PCBP4
     1  MSGSDGGLEE EPELSITLTL RMLMHGKEVG SIIGKKGETV KRIREQSSAR ITISEGSCPE
    61  RITTITGSTA AVFHAVSMIA FKLDEDLCAA PANGGNVSRP PVTLRLVIPA SQCGSLIGKA
   121  GTKIKEIRET TGAQVQVAGD LLPNSTERAV TVSGVPDAII LCVRQICAVI LESPPKGATI
   181  PYHPSLSLGT VLLSANQGFS VQGQYGAVTP AEVTKLQQLS SHAVPFATPS VVPGLDPGTQ
   241  TSSQEFLVPN DLIGCVIGRQ GSKISEIRQM SGAHIKIGNQ AEGAGERHVT ITGSPVSIAL
   301  AQYLITACLE TAKSTSGGTP SSAPADLPAP FSPPLTALPT APPGLLGTPY AISLSNFIGL
   361  KPMPFLALPP ASPGPPPGLA AYTAKMAAAN GSKKAERQKF SPY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PCBP4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 364 nTPM

Expression across tissuesHPA

Tissue

retina: 364 nTPM
cerebellum: 257 nTPM
spinal cord: 155 nTPM
skeletal muscle: 148 nTPM
midbrain: 96 nTPM
hippocampal formation: 94 nTPM

Single-cell type

cone photoreceptor cells: 377 nCPM
rod photoreceptor cells: 255 nCPM
retinal bipolar cells: 230 nCPM
late spermatids: 167 nCPM
oligodendrocytes: 94 nCPM
retinal pigment epithelial cells: 73 nCPM

Immune cell

T-reg: 12 nTPM
gdT-cell: 11 nTPM
memory CD8 T-cell: 11 nTPM
memory CD4 T-cell: 11 nTPM
MAIT T-cell: 7.8 nTPM
basophil: 7 nTPM

Brain region

white matter: 199 nTPM
medulla oblongata: 160 nTPM
basal ganglia: 146 nTPM
cerebral cortex: 140 nTPM
midbrain: 138 nTPM
thalamus: 137 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.7
gnomAD pLI: 0
gnomAD missense Z: 1.65
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PCBP4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

HSPA8

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PCBP4 as an antibody target. Whether an autoantibody or antibody against PCBP4 could matter depends on whether native PCBP4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PCBP4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PCBP4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...