Seroatlas · Human Serome Atlas

KHSRP

Far upstream element-binding protein 2

Also known as: FBP2, FUBP2, FUBP2_HUMAN, KSRP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q92945
Gene: KHSRP
Ensembl: ENSG00000088247
Chromosome: 19
Canonical length: 711 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

The KHSRP gene encodes a multifunctional RNA-binding protein implicated in a variety of cellular processes, including transcription, alternative pre-mRNA splicing, and mRNA localization (Min et al., 1997 [PubMed 9136930]; Gherzi et al., 2004 [PubMed 15175153]).[supplied by OMIM, Apr 2010]

Canonical amino-acid sequenceUniProt

711 residues, UniProt reviewed canonical sequence.

>Q92945|KHSRP
     1  MSDYSTGGPP PGPPPPAGGG GGAGGAGGGP PPGPPGAGDR GGGGPGGGGP GGGSAGGPSQ
    61  PPGGGGPGIR KDAFADAVQR ARQIAAKIGG DAATTVNNST PDFGFGGQKR QLEDGDQPES
   121  KKLASQGDSI SSQLGPIHPP PRTSMTEEYR VPDGMVGLII GRGGEQINKI QQDSGCKVQI
   181  SPDSGGLPER SVSLTGAPES VQKAKMMLDD IVSRGRGGPP GQFHDNANGG QNGTVQEIMI
   241  PAGKAGLVIG KGGETIKQLQ ERAGVKMILI QDGSQNTNVD KPLRIIGDPY KVQQACEMVM
   301  DILRERDQGG FGDRNEYGSR IGGGIDVPVP RHSVGVVIGR SGEMIKKIQN DAGVRIQFKQ
   361  DDGTGPEKIA HIMGPPDRCE HAARIINDLL QSLRSGPPGP PGGPGMPPGG RGRGRGQGNW
   421  GPPGGEMTFS IPTHKCGLVI GRGGENVKAI NQQTGAFVEI SRQLPPNGDP NFKLFIIRGS
   481  PQQIDHAKQL IEEKIEGPLC PVGPGPGGPG PAGPMGPFNP GPFNQGPPGA PPHAGGPPPH
   541  QYPPQGWGNT YPQWQPPAPH DPSKAAAAAA DPNAAWAAYY SHYYQQPPGP VPGPAPAPAA
   601  PPAQGEPPQP PPTGQSDYTK AWEEYYKKIG QQPQQPGAPP QQDYTKAWEE YYKKQAQVAT
   661  GGGPGAPPGS QPDYSAAWAE YYRQQAAYYG QTPGPGGPQP PPTQQGQQQA Q

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KHSRP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 75 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 75 nTPM
testis: 69 nTPM
endometrium: 68 nTPM
ovary: 68 nTPM
esophagus: 63 nTPM
cervix: 62 nTPM

Single-cell type

late primary spermatocytes: 142 nCPM
erythrocyte progenitors: 132 nCPM
megakaryocyte progenitors: 125 nCPM
monocyte progenitors: 107 nCPM
retinal pigment epithelial cells: 85 nCPM
ocular epithelial cells: 84 nCPM

Immune cell

plasmacytoid DC: 4.8 nTPM
naive B-cell: 3.3 nTPM
intermediate monocyte: 3.1 nTPM
memory CD8 T-cell: 2.9 nTPM
myeloid DC: 2.9 nTPM
non-classical monocyte: 2.8 nTPM

Brain region

white matter: 115 nTPM
amygdala: 107 nTPM
hippocampal formation: 106 nTPM
cerebral cortex: 105 nTPM
medulla oblongata: 102 nTPM
thalamus: 102 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.08
gnomAD pLI: 1
gnomAD missense Z: 3.83
DepMap mean gene effect: -0.19
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

K Homology domain
K Homology domain, type 1
Far upstream element-binding protein, C-terminal
K Homology domain, type 1 superfamily
KH domain
Far upstream element-binding protein, C-terminal
Far upstream element-binding protein 2, second type I K homology domain
Far upstream element-binding protein 2, third type I K homology domain
Far upstream element-binding protein 2, fourth type I K homology domain
Far upstream element-binding protein 2, first type I K homology domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KHSRP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KHSRP as an antibody target. Whether an autoantibody or antibody against KHSRP could matter depends on whether native KHSRP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KHSRP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KHSRP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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