Seroatlas · Human Serome Atlas

FUBP3

Far upstream element-binding protein 3

Also known as: FBP3, FUBP3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96I24
Gene
FUBP3
Ensembl
ENSG00000107164
Chromosome
9
Canonical length
572 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

Enables single-stranded DNA binding activity. Involved in DNA-templated transcription; positive regulation of DNA-templated transcription; and positive regulation of gene expression. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

572 residues, UniProt reviewed canonical sequence.

>Q96I24|FUBP3
     1  MAELVQGQSA PVGMKAEGFV DALHRVRQIA AKIDSIPHLN NSTPLVDPSV YGYGVQKRPL
    61  DDGVGNQLGA LVHQRTVITE EFKVPDKMVG FIIGRGGEQI SRIQAESGCK IQIASESSGI
   121  PERPCVLTGT PESIEQAKRL LGQIVDRCRN GPGFHNDIDS NSTIQEILIP ASKVGLVIGR
   181  GGETIKQLQE RTGVKMVMIQ DGPLPTGADK PLRITGDAFK VQQAREMVLE IIREKDQADF
   241  RGVRGDFNSR MGGGSIEVSV PRFAVGIVIG RNGEMIKKIQ NDAGVRIQFK PDDGISPERA
   301  AQVMGPPDRC QHAAHIISEL ILTAQERDGF GGLAAARGRG RGRGDWSVGA PGGVQEITYT
   361  VPADKCGLVI GKGGENIKSI NQQSGAHVEL QRNPPPNSDP NLRRFTIRGV PQQIEVARQL
   421  IDEKVGGTNL GAPGAFGQSP FSQPPAPPHQ NTFPPRSSGC FPNMAAKVNG NPHSTPVSGP
   481  PAFLTQGWGS TYQAWQQPTQ QVPSQQSQPQ SSQPNYSKAW EDYYKKQSHA ASAAPQASSP
   541  PDYTMAWAEY YRQQVAFYGQ TLGQAQAHSQ EQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FUBP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.51
Highest tissue expression
37 nTPM

Expression across tissuesHPA

Tissue

  • thyroid gland: 37 nTPM
  • liver: 36 nTPM
  • parathyroid gland: 30 nTPM
  • blood vessel: 29 nTPM
  • endometrium: 28 nTPM
  • cerebral cortex: 27 nTPM

Single-cell type

  • sertoli cells: 117 nCPM
  • syncytiotrophoblasts: 113 nCPM
  • müller glia: 106 nCPM
  • myonuclei: 97 nCPM
  • renal collecting duct intercalated cells: 96 nCPM
  • cardiomyocytes: 93 nCPM

Immune cell

  • NK-cell: 3.5 nTPM
  • MAIT T-cell: 3 nTPM
  • naive CD4 T-cell: 2.6 nTPM
  • myeloid DC: 2.3 nTPM
  • memory CD8 T-cell: 2.2 nTPM
  • plasmacytoid DC: 2.2 nTPM

Brain region

  • medulla oblongata: 25 nTPM
  • white matter: 24 nTPM
  • basal ganglia: 22 nTPM
  • cerebellum: 21 nTPM
  • midbrain: 21 nTPM
  • spinal cord: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.36
gnomAD pLI
0.8
gnomAD missense Z
2.17
DepMap mean gene effect
0.08
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FUBP3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FUBP3 as an antibody target. Whether an autoantibody or antibody against FUBP3 could matter depends on whether native FUBP3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FUBP3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FUBP3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FUBP3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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