Seroatlas · Human Serome Atlas

PCBP3

Poly(rC)-binding protein 3

Also known as: FLJ44028, PCBP3_HUMAN, PCBP3-OT1, PCBP3OT

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P57721
Gene: PCBP3
Ensembl: ENSG00000183570
Chromosome: 21
Canonical length: 371 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles,Mitochondria

OverviewNCBI Gene

This gene encodes a member of the KH-domain protein subfamily. Proteins of this subfamily, also referred to as alpha-CPs, bind to RNA with a specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. The protein encoded by this gene lacks the nuclear localization signals found in other subfamily members. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2017]

Canonical amino-acid sequenceUniProt

371 residues, UniProt reviewed canonical sequence.

>P57721|PCBP3
     1  MGEGDAFWAP SVLPHSTLST LSHHPQPQFG RRMESKVSEG GLNVTLTIRL LMHGKEVGSI
    61  IGKKGETVKK MREESGARIN ISEGNCPERI VTITGPTDAI FKAFAMIAYK FEEDIINSMS
   121  NSPATSKPPV TLRLVVPASQ CGSLIGKGGS KIKEIRESTG AQVQVAGDML PNSTERAVTI
   181  SGTPDAIIQC VKQICVVMLE SPPKGATIPY RPKPASTPVI FAGGQAYTIQ GQYAIPHPDQ
   241  LTKLHQLAMQ QTPFPPLGQT NPAFPGEKLP LHSSEEAQNL MGQSSGLDAS PPASTHELTI
   301  PNDLIGCIIG RQGTKINEIR QMSGAQIKIA NATEGSSERQ ITITGTPANI SLAQYLINAR
   361  LTSEVTGMGT L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PCBP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 76 nTPM

Expression across tissuesHPA

Tissue

retina: 76 nTPM
cerebellum: 59 nTPM
pituitary gland: 22 nTPM
thymus: 18 nTPM
testis: 14 nTPM
colon: 13 nTPM

Single-cell type

cone photoreceptor cells: 1,290 nCPM
rod photoreceptor cells: 1,187 nCPM
retinal bipolar cells: 742 nCPM
retinal ganglion cells: 634 nCPM
corticotrophs: 569 nCPM
thymocytes: 418 nCPM

Immune cell

eosinophil: 3 nTPM
basophil: 2.1 nTPM
naive B-cell: 1.4 nTPM
memory B-cell: 1.3 nTPM
gdT-cell: 0.7 nTPM
naive CD4 T-cell: 0.7 nTPM

Brain region

cerebellum: 71 nTPM
pons: 67 nTPM
medulla oblongata: 42 nTPM
thalamus: 36 nTPM
hippocampal formation: 27 nTPM
midbrain: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.39
gnomAD pLI: 0.84
gnomAD missense Z: 2.02
DepMap mean gene effect: 0.15
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

mRNA binding
RNA binding
C-rich single-stranded DNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PCBP3 as an antibody target. Whether an autoantibody or antibody against PCBP3 could matter depends on whether native PCBP3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PCBP3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PCBP3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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