Seroatlas · Human Serome Atlas

TDRKH

Tudor and KH domain-containing protein

Also known as: TDRD2, TDRKH_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y2W6
Gene: TDRKH
Ensembl: ENSG00000182134
Chromosome: 1
Canonical length: 561 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Centrosome,Cytosol

OverviewNCBI Gene

Predicted to enable RNA binding activity. Predicted to be involved in several processes, including P granule organization; male meiotic nuclear division; and piRNA processing. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

561 residues, UniProt reviewed canonical sequence.

>Q9Y2W6|TDRKH
     1  MSTERTSWTS LSTIQKIALG LGIPASATVA YILYRRYRES REERLTFVGE DDIEIEMRVP
    61  QEAVKLIIGR QGANIKQLRK QTGARIDVDT EDVGDERVLL ISGFPVQVCK AKAAIHQILT
   121  ENTPVSEQLS VPQRSVGRII GRGGETIRSI CKASGAKITC DKESEGTLLL SRLIKISGTQ
   181  KEVAAAKHLI LEKVSEDEEL RKRIAHSAET RVPRKQPISV RREDMTEPGG AGEPALWKNT
   241  SSSMEPTAPL VTPPPKGGGD MAVVVSKEGS WEKPSDDSFQ KSEAQAIPEM PMFEIPSPDF
   301  SFHADEYLEV YVSASEHPNH FWIQIVGSRS LQLDKLVNEM TQHYENSVPE DLTVHVGDIV
   361  AAPLPTNGSW YRARVLGTLE NGNLDLYFVD FGDNGDCPLK DLRALRSDFL SLPFQAIECS
   421  LARIAPSGDQ WEEEALDEFD RLTHCADWKP LVAKISSYVQ TGISTWPKIY LYDTSNGKKL
   481  DIGLELVHKG YAIELPEDIE ENRAVPDMLK DMATETDASL STLLTETKKS SGEITHTLSC
   541  LSLSEAASMS GDDNLEDDYL L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TDRKH can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 28 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 28 nTPM
testis: 21 nTPM
cerebellum: 13 nTPM
thymus: 9.4 nTPM
retina: 8.9 nTPM
cerebral cortex: 7.2 nTPM

Single-cell type

late spermatids: 112 nCPM
oocytes: 83 nCPM
early primary spermatocytes: 61 nCPM
breast lactating cells: 47 nCPM
platelets: 47 nCPM
late primary spermatocytes: 47 nCPM

Immune cell

MAIT T-cell: 13 nTPM
T-reg: 10 nTPM
memory CD8 T-cell: 8.3 nTPM
gdT-cell: 8.2 nTPM
non-classical monocyte: 8.1 nTPM
NK-cell: 7.7 nTPM

Brain region

pons: 18 nTPM
cerebellum: 17 nTPM
medulla oblongata: 14 nTPM
hypothalamus: 13 nTPM
thalamus: 12 nTPM
midbrain: 12 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TDRKH.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 68 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Azoospermia

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.52
gnomAD pLI: 0.03
gnomAD missense Z: 1.8
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 15% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Tudor domain
K Homology domain
K Homology domain, type 1
SNase-like, OB-fold superfamily
K Homology domain, type 1 superfamily
Tudor domain-containing
KH domain
Tudor domain
Tudor domain-containing protein 2-like, tudor domain
Tudor and KH domain-containing protein, second type I K homology domain
Tudor and KH domain-containing protein, first type I K homology domain

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TDRKH as an antibody target. Whether an autoantibody or antibody against TDRKH could matter depends on whether native TDRKH is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TDRKH is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TDRKH as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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