Seroatlas · Human Serome Atlas

MEX3D

RNA-binding protein MEX3D

Also known as: KIAA2031, MEX3D_HUMAN, OK/SW-cl.4, RKHD1, RNF193, Tino

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q86XN8
Gene
MEX3D
Ensembl
ENSG00000181588
Chromosome
19
Canonical length
651 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Enables mRNA 3'-UTR AU-rich region binding activity. Predicted to be involved in mRNA destabilization and mRNA localization resulting in post-transcriptional regulation of gene expression. Located in nucleus and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

651 residues, UniProt reviewed canonical sequence.

>Q86XN8|MEX3D
     1  MPSSLGQPDG GGGGGGGGGG VGAAGEDPGP GPAPPPEGAQ EAAPAPRPPP EPDDAAAALR
    61  LALDQLSALG LGGAGDTDEE GAAGDGAAAA GGADGGAAPE PVPPDGPEAG APPTLAPAVA
   121  PGSLPLLDPN ASPPPPPPPR PSPPDVFAGF APHPAALGPP TLLADQMSVI GSRKKSVNMT
   181  ECVPVPSSEH VAEIVGRQGC KIKALRAKTN TYIKTPVRGE EPVFIVTGRK EDVEMAKREI
   241  LSAAEHFSII RATRSKAGGL PGAAQGPPNL PGQTTIQVRV PYRVVGLVVG PKGATIKRIQ
   301  QRTHTYIVTP GRDKEPVFAV TGMPENVDRA REEIEAHITL RTGAFTDAGP DSDFHANGTD
   361  VCLDLLGAAA SLWAKTPNQG RRPPTATAGL RGDTALGAPS APEAFYAGSR GGPSVPDPGP
   421  ASPYSGSGNG GFAFGAEGPG APVGTAAPDD CDFGFDFDFL ALDLTVPAAA TIWAPFERAA
   481  PLPAFSGCST VNGAPGPPAA GARRSSGAGT PRHSPTLPEP GGLRLELPLS RRGAPDPVGA
   541  LSWRPPQGPV SFPGGAAFST ATSLPSSPAA AACAPLDSGA SENSRKPPSA SSAPALAREC
   601  VVCAEGEVMA ALVPCGHNLF CMDCAVRICG KSEPECPACR TPATQAIHIF S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MEX3D can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.61
Highest tissue expression
74 nTPM

Expression across tissuesHPA

Tissue

  • testis: 74 nTPM
  • ovary: 12 nTPM
  • spinal cord: 11 nTPM
  • endometrium: 11 nTPM
  • skin: 10 nTPM
  • esophagus: 9.1 nTPM

Single-cell type

  • late spermatids: 605 nCPM
  • early spermatids: 94 nCPM
  • breast hormone-responsive cells: 33 nCPM
  • mucous neck cells: 24 nCPM
  • ocular epithelial cells: 24 nCPM
  • adrenal medulla cells: 21 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • white matter: 49 nTPM
  • medulla oblongata: 47 nTPM
  • cerebral cortex: 39 nTPM
  • amygdala: 36 nTPM
  • thalamus: 35 nTPM
  • basal ganglia: 34 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.36
gnomAD pLI
0.92
gnomAD missense Z
2.47
DepMap mean gene effect
0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MEX3D as an antibody target. Whether an autoantibody or antibody against MEX3D could matter depends on whether native MEX3D is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MEX3D is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MEX3D as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MEX3D. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...