BICC1

Protein identityUniProt · HPA

UniProt accession

Q9H694

Gene

BICC1

Ensembl

ENSG00000122870

Chromosome

10

Canonical length

974 aa

Protein class

Disease related genes, Predicted intracellular proteins

Subcellular location

Centrosome,Cytosol

OverviewNCBI Gene

This gene encodes an RNA-binding protein that is active in regulating gene expression by modulating protein translation during embryonic development. Mouse studies identified the corresponding protein to be under strict control during cell differentiation and to be a maternally provided gene product. [provided by RefSeq, Apr 2009]

Canonical amino-acid sequenceUniProt

974 residues, UniProt reviewed canonical sequence.

>Q9H694|BICC1
     1  MAAQGEPGYL AAQSDPGSNS ERSTDSPVPG SEDDLVAGAT LHSPEWSEER FRVDRKKLEA
    61  MLQAAAEGKG RSGEDFFQKI MEETNTQIAW PSKLKIGAKS KKDPHIKVSG KKEDVKEAKE
   121  MIMSVLDTKS NRVTLKMDVS HTEHSHVIGK GGNNIKKVME ETGCHIHFPD SNRNNQAEKS
   181  NQVSIAGQPA GVESARVRIR ELLPLVLMFE LPIAGILQPV PDPNSPSIQH ISQTYNISVS
   241  FKQRSRMYGA TVIVRGSQNN TSAVKEGTAM LLEHLAGSLA SAIPVSTQLD IAAQHHLFMM
   301  GRNGSNIKHI MQRTGAQIHF PDPSNPQKKS TVYLQGTIES VCLARQYLMG CLPLVLMFDM
   361  KEEIEVDPQF IAQLMEQLDV FISIKPKPKQ PSKSVIVKSV ERNALNMYEA RKCLLGLESS
   421  GVTIATSPSP ASCPAGLACP SLDILASAGL GLTGLGLLGP TTLSLNTSTT PNSLLNALNS
   481  SVSPLQSPSS GTPSPTLWAP PLANTSSATG FSAIPHLMIP STAQATLTNI LLSGVPTYGH
   541  TAPSPPPGLT PVDVHINSMQ TEGKKISAAL NGHAQSPDIK YGAISTSSLG EKVLSANHGD
   601  PSIQTSGSEQ TSPKSSPTEG CNDAFVEVGM PRSPSHSGNA GDLKQMMCPS KVSCAKRQTV
   661  ELLQGTKNSH LHSTDRLLSD PELSATESPL ADKKAPGSER AAERAAAAQQ NSERAHLAPR
   721  SSYVNMQAFD YEQKKLLATK AMLKKPVVTE VRTPTNTWSG LGFSKSMPAE TIKELRRANH
   781  VSYKPTMTTT YEGSSMSLSR SNSREHLGGG SESDNWRDRN GIGPGSHSEF AASIGSPKRK
   841  QNKSTEHYLS SSNYMDCISS LTGSNGCNLN SSFKGSDLPE LFSKLGLGKY TDVFQQQEID
   901  LQTFLTLTDQ DLKELGITTF GARRKMLLAI SELNKNRRKL FESPNARTSF LEGGASGRLP
   961  RQYHSDIASV SGRW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BICC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.52

Highest tissue expression

27 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about BICC1.

Disease | AllUniProt

Conditions BICC1 is implicated in, by any mechanism.

• Renal dysplasia, cystic (CYSRD) MIM:601331

Disease | GeneticClinVar

5 pathogenic / likely-pathogenic of 452 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Renal dysplasia, cystic, susceptibility to
• Renal agenesis

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.34

gnomAD pLI

0.84

gnomAD missense Z

1.25

DepMap mean gene effect

-0.04

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• determination of left/right symmetry
• heart development
• kidney development
• mRNA catabolic process
• negative regulation of canonical Wnt signaling pathway

Molecular functions

• RNA binding

Cellular components

• cytoplasm

Protein domainsUniProt · Pfam · InterPro

• Sterile alpha motif domain
• K Homology domain
• K Homology domain, type 1
• Sterile alpha motif/pointed domain superfamily
• K Homology domain, type 1 superfamily
• KH domain
• SAM domain (Sterile alpha motif)
• BICC1, SAM domain
• BICC1, first type I KH domain
• BICC1, third type I KH domain
• BICC1, second type I KH
• Protein bicaudal C homolog 1, KH-like domain
• Protein bicaudal C homolog 1, KH-like domain
• BICC1, first type I KH domain

KeywordsUniProt

• Acetylation
• Cytoplasm
• Developmental protein
• Phosphoprotein
• Repeat
• RNA-binding

InteractionsUniProt · HPA

Protein binding partners of BICC1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ANKS3