HECT, E3 ligase catalytic domain
IPR035983
Definition
The HECT (Homologous to the E6-AP Carboxyl Terminus) domain is an around 350 amino acids motif that has been identified in proteins that all belong to a particular E3 ubiquitin-protein ligase family PMID:7708685. HECT domain containing proteins accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then transfer it to lysine side chains of target proteins, and transfers additional ubiquitin molecules to the end of growing ubiquitin chains. The site of ubiquitin thioester formation is a conserved cysteine residue located in the last 32-36 aa of the HECT domain PMID:7708685. The amino-terminal part of the HECT domain has been involved in E2 binding [[cite:PMID:9182527], [cite:PMID:9153201]]. Once linked to ubiquitin, the target proteins are degraded in the 26 S proteasome.
28 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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