WBP1
WW domain-binding protein 1
Also known as: WBP-1, WBP1_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q96G27
- Gene
- WBP1
- Ensembl
- ENSG00000239779
- Chromosome
- 2
- Canonical length
- 269 aa
- Protein class
- Predicted membrane proteins
- Subcellular location
- Cytosol
OverviewNCBI Gene
The globular WW domain, named for the conserved tryptophan residues in the protein motif present in various structural and regulatory proteins, is known to play a role in the mediation of protein-protein interactions. This gene encodes a ligand of the WW domain of the Yes kinase-associated protein. Readthrough transcription of the neighboring upstream gene, which encodes INO80 complex subunit B, into this gene generates a non-coding transcript. [provided by RefSeq, Feb 2011]
Canonical amino-acid sequenceUniProt
269 residues, UniProt reviewed canonical sequence.
>Q96G27|WBP1
1 MARASSGNGS EEAWGALRAP QQQLRELCPG VNNQPYLCES GHCCGETGCC TYYYELWWFW
61 LLWTVLILFS CCCAFRHRRA KLRLQQQQRQ REINLLAYHG ACHGAGPFPT GSLLDLRFLS
121 TFKPPAYEDV VHRPGTPPPP YTVAPGRPLT ASSEQTCCSS SSSCPAHFEG TNVEGVSSHQ
181 SAPPHQEGEP GAGVTPASTP PSCRYRRLTG DSGIELCPCP ASGEGEPVKE VRVSATLPDL
241 EDYSPCALPP ESVPQIFPMG LSSSEGDIPLocalizationUniProt · AlphaFold · HPA
Whether an antibody against WBP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.64
- Highest tissue expression
- 123 nTPM
Expression across tissuesHPA
Tissue
- amygdala: 123 nTPM
- basal ganglia: 111 nTPM
- hippocampal formation: 104 nTPM
- cerebral cortex: 101 nTPM
- midbrain: 98 nTPM
- choroid plexus: 89 nTPM
Single-cell type
- bergmann glia: 29 nCPM
- oligodendrocytes: 26 nCPM
- ependymal cells: 25 nCPM
- astrocytes: 23 nCPM
- oligodendrocyte progenitor cells: 17 nCPM
- other brain neurons: 16 nCPM
Immune cell
- plasmacytoid DC: 47 nTPM
- T-reg: 39 nTPM
- NK-cell: 35 nTPM
- naive CD4 T-cell: 31 nTPM
- myeloid DC: 30 nTPM
- classical monocyte: 29 nTPM
Brain region
- thalamus: 70 nTPM
- basal ganglia: 69 nTPM
- medulla oblongata: 67 nTPM
- amygdala: 61 nTPM
- midbrain: 60 nTPM
- cerebellum: 56 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.41
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.55
- DepMap mean gene effect
- -0.48
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Molecular functions
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of WBP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads WBP1 as an antibody target. Whether an autoantibody or antibody against WBP1 could matter depends on whether native WBP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
WBP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label WBP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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