RBP1
Retinol-binding protein 1
Also known as: CRABP-I, CRBP, CRBP1, CRBPI, RBPC, RET1_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P09455
- Gene
- RBP1
- Ensembl
- ENSG00000114115
- Chromosome
- 3
- Canonical length
- 135 aa
- Protein class
- Metabolic proteins, Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Cytosol
OverviewNCBI Gene
This gene encodes the carrier protein involved in the transport of retinol (vitamin A alcohol) from the liver storage site to peripheral tissue. Vitamin A is a fat-soluble vitamin necessary for growth, reproduction, differentiation of epithelial tissues, and vision. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Canonical amino-acid sequenceUniProt
135 residues, UniProt reviewed canonical sequence.
>P09455|RBP1
1 MPVDFTGYWK MLVNENFEEY LRALDVNVAL RKIANLLKPD KEIVQDGDHM IIRTLSTFRN
61 YIMDFQVGKE FEEDLTGIDD RKCMTTVSWD GDKLQCVQKG EKEGRGWTQW IEGDELHLEM
121 RVEGVVCKQV FKKVQLocalizationUniProt · AlphaFold · HPA
Whether an antibody against RBP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.29
- Highest tissue expression
- 1,363 nTPM
Expression across tissuesHPA
Tissue
- ovary: 1,363 nTPM
- choroid plexus: 1,160 nTPM
- pancreas: 610 nTPM
- adrenal gland: 374 nTPM
- fallopian tube: 366 nTPM
- pituitary gland: 254 nTPM
Single-cell type
- retinal pigment epithelial cells: 3,103 nCPM
- ovarian stromal cells: 2,164 nCPM
- decidual stromal cells: 2,029 nCPM
- granulosa cells: 1,610 nCPM
- fallopian tube ciliated cells: 1,371 nCPM
- hepatic stellate cells: 768 nCPM
Immune cell
- neutrophil: 0.3 nTPM
- basophil: 0.2 nTPM
- classical monocyte: 0.1 nTPM
- eosinophil: 0.1 nTPM
- intermediate monocyte: 0.1 nTPM
- NK-cell: 0.1 nTPM
Brain region
- choroid plexus: 440 nTPM
- medulla oblongata: 87 nTPM
- thalamus: 68 nTPM
- midbrain: 56 nTPM
- spinal cord: 54 nTPM
- hypothalamus: 52 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.7
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.62
- DepMap mean gene effect
- 0.1
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of RBP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads RBP1 as an antibody target. Whether an autoantibody or antibody against RBP1 could matter depends on whether native RBP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
RBP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label RBP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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