Seroatlas · Human Serome Atlas

LGALS9B

Galectin-9B

Also known as: LEG9B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q3B8N2
Gene: LGALS9B
Ensembl: ENSG00000170298
Chromosome: 17
Canonical length: 356 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

This gene was initially thought to represent a pseudogene of galectin 9; however, this transcript has good exon-intron structure and encodes a predicted protein of the same size as and highly similar to galectin 9. This gene is one of two similar loci on chromosome 17p similar to galectin 9 and now thought to be protein-encoding. This gene is the more centromeric gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

356 residues, UniProt reviewed canonical sequence.

>Q3B8N2|LGALS9B
     1  MAFSGSQAPY LSPAVPFSGT IQGGLQDGFQ ITVNGAVLSS SGTRFAVDFQ TGFSGNDIAF
    61  HFNPRFEDGG YVVCNTRQKG RWGPEERKMH MPFQKGMPFD LCFLVQSSDF KVMVNGSLFV
   121  QYFHRVPFHR VDTISVNGSV QLSYISFQNP RTVPVQPAFS TVPFSQPVCF PPRPRGRRQK
   181  PPSVRPANPA PITQTVIHTV QSASGQMFSQ TPAIPPMMYP HPAYPMPFIT TIPGGLYPSK
   241  SIILSGTVLP SAQRFHINLC SGSHIAFHMN PRFDENAVVR NTQINNSWGS EERSLPRKMP
   301  FVRGQSFSVW ILCEAHCLKV AVDGQHVFEY YHRLRNLPTI NKLEVGGDIQ LTHVQT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LGALS9B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 29 nTPM

Expression across tissuesHPA

Tissue

stomach: 29 nTPM
esophagus: 15 nTPM
rectum: 10 nTPM
colon: 7.7 nTPM
gallbladder: 7 nTPM
vagina: 4 nTPM

Single-cell type

foveolar cells: 220 nCPM
goblet cells: 68 nCPM
esophageal apical cells: 29 nCPM
colonocytes: 19 nCPM
respiratory secretory cells: 11 nCPM
respiratory deuterosomal cells: 10 nCPM

Immune cell

NK-cell: 13 nTPM
total PBMC: 2 nTPM
gdT-cell: 0.8 nTPM
naive CD8 T-cell: 0.4 nTPM
myeloid DC: 0.3 nTPM
non-classical monocyte: 0.3 nTPM

Brain region

hippocampal formation: 0.3 nTPM
cerebral cortex: 0.1 nTPM
medulla oblongata: 0.1 nTPM
midbrain: 0.1 nTPM
spinal cord: 0.1 nTPM
white matter: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.17
gnomAD pLI: 0
gnomAD missense Z: 0.54
DepMap mean gene effect: -0.34
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LGALS9B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

WWP2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LGALS9B as an antibody target. Whether an autoantibody or antibody against LGALS9B could matter depends on whether native LGALS9B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LGALS9B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LGALS9B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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