Seroatlas · Human Serome Atlas

WBP2

WW domain-binding protein 2

Also known as: GRAMD6, WBP-2, WBP2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q969T9
Gene: WBP2
Ensembl: ENSG00000132471
Chromosome: 17
Canonical length: 261 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

The globular WW domain is composed of 38 to 40 semiconserved amino acids shared by proteins of diverse functions including structural, regulatory, and signaling proteins. The domain is involved in mediating protein-protein interactions through the binding of polyproline ligands. This gene encodes a WW domain binding protein that is a transcriptional coactivator of estrogen receptor alpha and progesterone receptor. Defects in this gene have been associated with hearing impairment. [provided by RefSeq, Jan 2017]

Canonical amino-acid sequenceUniProt

261 residues, UniProt reviewed canonical sequence.

>Q969T9|WBP2
     1  MALNKNHSEG GGVIVNNTES ILMSYDHVEL TFNDMKNVPE AFKGTKKGTV YLTPYRVIFL
    61  SKGKDAMQSF MMPFYLMKDC EIKQPVFGAN YIKGTVKAEA GGGWEGSASY KLTFTAGGAI
   121  EFGQRMLQVA SQASRGEVPS GAYGYSYMPS GAYVYPPPVA NGMYPCPPGY PYPPPPPEFY
   181  PGPPMMDGAM GYVQPPPPPY PGPMEPPVSG PDVPSTPAAE AKAAEAAASA YYNPGNPHNV
   241  YMPTSQPPPP PYYPPEDKKT Q

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WBP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.49
Highest tissue expression: 391 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 391 nTPM
midbrain: 300 nTPM
cerebellum: 297 nTPM
amygdala: 294 nTPM
hippocampal formation: 289 nTPM
spinal cord: 285 nTPM

Single-cell type

platelets: 904 nCPM
late spermatids: 485 nCPM
early spermatids: 342 nCPM
esophageal apical cells: 279 nCPM
syncytiotrophoblasts: 264 nCPM
breast lactating cells: 245 nCPM

Immune cell

neutrophil: 310 nTPM
eosinophil: 289 nTPM
basophil: 242 nTPM
non-classical monocyte: 137 nTPM
intermediate monocyte: 103 nTPM
total PBMC: 93 nTPM

Brain region

pons: 475 nTPM
cerebral cortex: 465 nTPM
medulla oblongata: 444 nTPM
thalamus: 419 nTPM
midbrain: 409 nTPM
white matter: 387 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about WBP2.

Disease | AllUniProt

Conditions WBP2 is implicated in, by any mechanism.

Deafness, autosomal recessive, 107 (DFNB107) MIM:617639

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 157 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Hearing loss, autosomal recessive 107

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.59
gnomAD pLI: 0.35
gnomAD missense Z: 0.3
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of WBP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WBP2 as an antibody target. Whether an autoantibody or antibody against WBP2 could matter depends on whether native WBP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WBP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label WBP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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