E3 ubiquitin-protein ligase
IPR050409
Definition
The protein family described is involved in the ubiquitination process, where members act as E3 ubiquitin-protein ligases. These enzymes accept ubiquitin from E2 ubiquitin-conjugating enzymes as thioesters and transfer them directly to target substrates. This post-translational modification can lead to various outcomes, including proteasomal degradation, altered cellular location, or changes in activity of the substrate proteins. The family members regulate diverse biological processes such as signal transduction, cell cycle progression, apoptosis, DNA repair, mRNA export, rRNA maturation, and immune responses. Some proteins within the family also have roles in regulating membrane dynamics, neuronal development, and autophagy. They are characterized by the presence of HECT, WW, or C2 domains, which mediate interactions with substrates and regulatory proteins, and are involved in autoinhibition and activation of the ligase activity.
12 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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