ENTREP1
Endosomal transmembrane epsin interactor 1
Also known as: C9orf61, ENTREP, EREP1_HUMAN, FAM189A2, X123
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q15884
- Gene
- ENTREP1
- Ensembl
- ENSG00000135063
- Chromosome
- 9
- Canonical length
- 450 aa
- Protein class
- Predicted membrane proteins
OverviewNCBI Gene
Enables ubiquitin ligase activator activity. Involved in CXCL12-activated CXCR4 signaling pathway and negative adaptation of signaling pathway. Located in endosome membrane and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
450 residues, UniProt reviewed canonical sequence.
>Q15884|ENTREP1
1 MILLVNLFVL LSVVCVLLNL AGFILGCQGA QFVSSVPRCD LVDLGEGKIC FCCEEFQPAK
61 CTDKENALKL FPVQPCSAVH LLLKKVLFAL CALNALTTTV CLVAAALRYL QIFATRRSCI
121 DESQISAEEA EDHGRIPDPD DFVPPVPPPS YFATFYSCTP RMNRRMVGPD VIPLPHIYGA
181 RIKGVEVFCP LDPPPPYEAV VSQMDQEQGS SFQMSEGSEA AVIPLDLGCT QVTQDGDIPN
241 IPAEENASTS TPSSTLVRPI RSRRALPPLR TRSKSDPVLH PSEERAAPVL SCEAATQTER
301 RLDLAAVTLR RGLRSRASRC RPRSLIDYKS YMDTKLLVAR FLEQSSCTMT PDIHELVENI
361 KSVLKSDEEH MEEAITSASF LEQIMAPLQP STSRAHKLPS RRQPGLLHLQ SCGDLHTFTP
421 AGRPRAERRP RRVEAERPHS LIGVIRETVLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ENTREP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.58
- Highest tissue expression
- 50 nTPM
Expression across tissuesHPA
Tissue
- thyroid gland: 50 nTPM
- skeletal muscle: 46 nTPM
- cervix: 25 nTPM
- ovary: 22 nTPM
- lung: 21 nTPM
- stomach: 14 nTPM
Single-cell type
- astrocytes: 491 nCPM
- smooth muscle cells: 460 nCPM
- myonuclei: 354 nCPM
- thymic myoid cells: 257 nCPM
- gonadotrophs: 217 nCPM
- müller glia: 199 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- medulla oblongata: 38 nTPM
- thalamus: 38 nTPM
- midbrain: 31 nTPM
- spinal cord: 30 nTPM
- cerebellum: 29 nTPM
- hypothalamus: 29 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.11
- gnomAD pLI
- 0
- DepMap mean gene effect
- -0.14
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- CXCL12-activated CXCR4 signaling pathway
- receptor internalization
- negative adaptation of signaling pathway
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of ENTREP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ENTREP1 as an antibody target. Whether an autoantibody or antibody against ENTREP1 could matter depends on whether native ENTREP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ENTREP1 is annotated at the cell surface, where native ENTREP1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label ENTREP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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