Seroatlas · Human Serome Atlas

ARRDC4

Arrestin domain-containing protein 4

Also known as: ARRD4_HUMAN, FLJ36045

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8NCT1
Gene
ARRDC4
Ensembl
ENSG00000140450
Chromosome
15
Canonical length
418 aa
Protein class
Predicted intracellular proteins
Subcellular location
Vesicles,Plasma membrane

OverviewNCBI Gene

Enables ubiquitin-like ligase-substrate adaptor activity. Involved in positive regulation of interferon-beta production and protein K63-linked ubiquitination. Acts upstream of or within positive regulation of ubiquitin-protein transferase activity. Located in endosome and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

418 residues, UniProt reviewed canonical sequence.

>Q8NCT1|ARRDC4
     1  MGGEAGCAAA VGAEGRVKSL GLVFEDERKG CYSSGETVAG HVLLEASEPV ALRALRLEAQ
    61  GRATAAWGPS TCPRASASTA ALAVFSEVEY LNVRLSLREP PAGEGIILLQ PGKHEFPFRF
   121  QLPSEPLVTS FTGKYGSIQY CVRAVLERPK VPDQSVKREL QVVSHVDVNT PALLTPVLKT
   181  QEKMVGCWFF TSGPVSLSAK IERKGYCNGE AIPIYAEIEN CSSRLIVPKA AIFQTQTYLA
   241  SGKTKTIRHM VANVRGNHIA SGSTDTWNGK TLKIPPVTPS ILDCCIIRVD YSLAVYIHIP
   301  GAKKLMLELP LVIGTIPYNG FGSRNSSIAS QFSMDMSWLT LTLPEQPEAP PNYADVVSEE
   361  EFSRHIPPYP QPPNCEGEVC CPVFACIQEF RFQPPPLYSE VDPHPSDVEE SQPVSFIL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARRDC4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
76 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 76 nTPM
  • colon: 40 nTPM
  • skin: 34 nTPM
  • pancreas: 33 nTPM
  • liver: 28 nTPM
  • stomach: 25 nTPM

Single-cell type

  • podocytes: 243 nCPM
  • parietal cells: 133 nCPM
  • epididymal principal cells: 123 nCPM
  • colonocytes: 85 nCPM
  • ependymal cells: 57 nCPM
  • renal collecting duct intercalated cells: 54 nCPM

Immune cell

  • classical monocyte: 2.5 nTPM
  • intermediate monocyte: 1.7 nTPM
  • eosinophil: 1.5 nTPM
  • neutrophil: 1.4 nTPM
  • basophil: 1.1 nTPM
  • myeloid DC: 1.1 nTPM

Brain region

  • white matter: 157 nTPM
  • medulla oblongata: 149 nTPM
  • spinal cord: 83 nTPM
  • hypothalamus: 69 nTPM
  • pons: 55 nTPM
  • hippocampal formation: 50 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.13
gnomAD pLI
0
gnomAD missense Z
0.62
DepMap mean gene effect
0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ARRDC4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARRDC4 as an antibody target. Whether an autoantibody or antibody against ARRDC4 could matter depends on whether native ARRDC4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARRDC4 is annotated at the cell surface, where native ARRDC4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ARRDC4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ARRDC4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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