Seroatlas · Human Serome Atlas

ARRDC3

Arrestin domain-containing protein 3

Also known as: ARRD3_HUMAN, KIAA1376, TLIMP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96B67
Gene
ARRDC3
Ensembl
ENSG00000113369
Chromosome
5
Canonical length
414 aa
Protein class
Predicted intracellular proteins, Transporters

OverviewNCBI Gene

This gene encodes a member of the arrestin family of proteins, which regulate G protein-mediated signaling. The encoded protein is thought to act as a regulator of breast cancer growth and progression by binding to a phosphorylated form of integrin beta4, a tumor-related antigen, targeting the integrin for internalization and degradation. [provided by RefSeq, Jul 2016]

Canonical amino-acid sequenceUniProt

414 residues, UniProt reviewed canonical sequence.

>Q96B67|ARRDC3
     1  MVLGKVKSLT ISFDCLNDSN VPVYSSGDTV SGRVNLEVTG EIRVKSLKIH ARGHAKVRWT
    61  ESRNAGSNTA YTQNYTEEVE YFNHKDILIG HERDDDNSEE GFHTIHSGRH EYAFSFELPQ
   121  TPLATSFEGR HGSVRYWVKA ELHRPWLLPV KLKKEFTVFE HIDINTPSLL SPQAGTKEKT
   181  LCCWFCTSGP ISLSAKIERK GYTPGESIQI FAEIENCSSR MVVPKAAIYQ TQAFYAKGKM
   241  KEVKQLVANL RGESLSSGKT ETWNGKLLKI PPVSPSILDC SIIRVEYSLM VYVDIPGAMD
   301  LFLNLPLVIG TIPLHPFGSR TSSVSSQCSM NMNWLSLSLP ERPEAPPSYA EVVTEEQRRN
   361  NLAPVSACDD FERALQGPLF AYIQEFRFLP PPLYSEIDPN PDQSADDRPS CPSR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARRDC3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
158 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 158 nTPM
  • breast: 89 nTPM
  • thyroid gland: 79 nTPM
  • adrenal gland: 76 nTPM
  • placenta: 72 nTPM
  • liver: 71 nTPM

Single-cell type

  • adrenal cortex cells: 501 nCPM
  • pancreatic acinar cells: 484 nCPM
  • syncytiotrophoblasts: 455 nCPM
  • neutrophils: 247 nCPM
  • hepatocytes: 236 nCPM
  • lacrimal acinar cells: 217 nCPM

Immune cell

  • neutrophil: 116 nTPM
  • naive CD8 T-cell: 38 nTPM
  • gdT-cell: 29 nTPM
  • basophil: 29 nTPM
  • naive CD4 T-cell: 24 nTPM
  • memory CD8 T-cell: 23 nTPM

Brain region

  • white matter: 77 nTPM
  • medulla oblongata: 53 nTPM
  • choroid plexus: 44 nTPM
  • spinal cord: 44 nTPM
  • cerebellum: 43 nTPM
  • basal ganglia: 40 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.29
gnomAD pLI
0.99
gnomAD missense Z
1.87
DepMap mean gene effect
0.19
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ARRDC3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARRDC3 as an antibody target. Whether an autoantibody or antibody against ARRDC3 could matter depends on whether native ARRDC3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARRDC3 is annotated at the cell surface, where native ARRDC3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ARRDC3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ARRDC3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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