Seroatlas · Human Serome Atlas

PDLIM7

PDZ and LIM domain protein 7

Also known as: ENIGMA, PDLI7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NR12
Gene: PDLIM7
Ensembl: ENSG00000196923
Chromosome: 5
Canonical length: 457 aa
Protein class: Predicted intracellular proteins
Subcellular location: Actin filaments,Focal adhesion sites

OverviewNCBI Gene

The protein encoded by this gene is representative of a family of proteins composed of conserved PDZ and LIM domains. LIM domains are proposed to function in protein-protein recognition in a variety of contexts including gene transcription and development and in cytoskeletal interaction. The LIM domains of this protein bind to protein kinases, whereas the PDZ domain binds to actin filaments. The gene product is involved in the assembly of an actin filament-associated complex essential for transmission of ret/ptc2 mitogenic signaling. The biological function is likely to be that of an adapter, with the PDZ domain localizing the LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

457 residues, UniProt reviewed canonical sequence.

>Q9NR12|PDLIM7
     1  MDSFKVVLEG PAPWGFRLQG GKDFNVPLSI SRLTPGGKAA QAGVAVGDWV LSIDGENAGS
    61  LTHIEAQNKI RACGERLSLG LSRAQPVQSK PQKASAPAAD PPRYTFAPSV SLNKTARPFG
   121  APPPADSAPQ QNGQPLRPLV PDASKQRLME NTEDWRPRPG TGQSRSFRIL AHLTGTEFMQ
   181  DPDEEHLKKS SQVPRTEAPA PASSTPQEPW PGPTAPSPTS RPPWAVDPAF AERYAPDKTS
   241  TVLTRHSQPA TPTPLQSRTS IVQAAAGGVP GGGSNNGKTP VCHQCHKVIR GRYLVALGHA
   301  YHPEEFVCSQ CGKVLEEGGF FEEKGAIFCP PCYDVRYAPS CAKCKKKITG EIMHALKMTW
   361  HVHCFTCAAC KTPIRNRAFY MEEGVPYCER DYEKMFGTKC HGCDFKIDAG DRFLEALGFS
   421  WHDTCFVCAI CQINLEGKTF YSKKDRPLCK SHAFSHV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PDLIM7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 621 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 621 nTPM
colon: 568 nTPM
blood vessel: 550 nTPM
endometrium: 468 nTPM
urinary bladder: 316 nTPM
fallopian tube: 282 nTPM

Single-cell type

smooth muscle cells: 512 nCPM
decidual stromal cells: 380 nCPM
megakaryocytes: 321 nCPM
peritubular myoid cells: 290 nCPM
platelets: 255 nCPM
breast myoepithelial cells: 252 nCPM

Immune cell

neutrophil: 441 nTPM
basophil: 178 nTPM
eosinophil: 122 nTPM
classical monocyte: 47 nTPM
non-classical monocyte: 30 nTPM
myeloid DC: 27 nTPM

Brain region

choroid plexus: 36 nTPM
hypothalamus: 32 nTPM
cerebral cortex: 31 nTPM
basal ganglia: 29 nTPM
thalamus: 29 nTPM
pons: 25 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.43
gnomAD pLI: 0.71
gnomAD missense Z: 0.73
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PDLIM7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PDLIM7 as an antibody target. Whether an autoantibody or antibody against PDLIM7 could matter depends on whether native PDLIM7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PDLIM7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PDLIM7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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