Seroatlas · Human Serome Atlas

SLC11A2

Natural resistance-associated macrophage protein 2

Also known as: DCT1, DMT-1, DMT1, FLJ37416, NRAM2_HUMAN, NRAMP2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P49281
Gene
SLC11A2
Ensembl
ENSG00000110911
Chromosome
12
Canonical length
568 aa
Protein class
Disease related genes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location
Mitochondria

OverviewNCBI Gene

This gene encodes a member of the solute carrier family 11 protein family. The product of this gene transports divalent metals and is involved in iron absorption. Mutations in this gene are associated with hypochromic microcytic anemia with iron overload. A related solute carrier family 11 protein gene is located on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2010]

Canonical amino-acid sequenceUniProt

568 residues, UniProt reviewed canonical sequence.

>P49281|SLC11A2
     1  MVLGPEQKMS DDSVSGDHGE SASLGNINPA YSNPSLSQSP GDSEEYFATY FNEKISIPEE
    61  EYSCFSFRKL WAFTGPGFLM SIAYLDPGNI ESDLQSGAVA GFKLLWILLL ATLVGLLLQR
   121  LAARLGVVTG LHLAEVCHRQ YPKVPRVILW LMVELAIIGS DMQEVIGSAI AINLLSVGRI
   181  PLWGGVLITI ADTFVFLFLD KYGLRKLEAF FGFLITIMAL TFGYEYVTVK PSQSQVLKGM
   241  FVPSCSGCRT PQIEQAVGIV GAVIMPHNMY LHSALVKSRQ VNRNNKQEVR EANKYFFIES
   301  CIALFVSFII NVFVVSVFAE AFFGKTNEQV VEVCTNTSSP HAGLFPKDNS TLAVDIYKGG
   361  VVLGCYFGPA ALYIWAVGIL AAGQSSTMTG TYSGQFVMEG FLNLKWSRFA RVVLTRSIAI
   421  IPTLLVAVFQ DVEHLTGMND FLNVLQSLQL PFALIPILTF TSLRPVMSDF ANGLGWRIAG
   481  GILVLIICSI NMYFVVVYVR DLGHVALYVV AAVVSVAYLG FVFYLGWQCL IALGMSFLDC
   541  GHTCHLGLTA QPELYLLNTM DADSLVSR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC11A2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
12
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
51 nTPM

Expression across tissuesHPA

Tissue

  • duodenum: 51 nTPM
  • parathyroid gland: 40 nTPM
  • thyroid gland: 39 nTPM
  • salivary gland: 29 nTPM
  • breast: 28 nTPM
  • cervix: 28 nTPM

Single-cell type

  • renal connecting tubule cells: 153 nCPM
  • mast cells: 133 nCPM
  • oligodendrocytes: 122 nCPM
  • microglia: 121 nCPM
  • breast lactating cells: 118 nCPM
  • esophageal apical cells: 112 nCPM

Immune cell

  • myeloid DC: 7 nTPM
  • intermediate monocyte: 6.7 nTPM
  • NK-cell: 6 nTPM
  • non-classical monocyte: 4.8 nTPM
  • classical monocyte: 4.7 nTPM
  • naive CD4 T-cell: 4.6 nTPM

Brain region

  • white matter: 74 nTPM
  • medulla oblongata: 60 nTPM
  • pons: 57 nTPM
  • basal ganglia: 56 nTPM
  • cerebellum: 54 nTPM
  • spinal cord: 53 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLC11A2.

Disease | AllUniProt

Conditions SLC11A2 is implicated in, by any mechanism.

  • Anemia, hypochromic microcytic, with iron overload 1 (AHMIO1) MIM:206100

Disease | GeneticClinVar

8 pathogenic / likely-pathogenic of 176 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Microcytic anemia with liver iron overload
  • SLC11A2-related disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.53
gnomAD pLI
0.01
gnomAD missense Z
2.23
DepMap mean gene effect
-0.17
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLC11A2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC11A2 as an antibody target. Whether an autoantibody or antibody against SLC11A2 could matter depends on whether native SLC11A2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC11A2 is annotated at the cell surface, where native SLC11A2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC11A2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC11A2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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